{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:17:13Z","timestamp":1791929833261,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"MiMedx Group, Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A randomised, controlled, multicentre clinical trial was conducted to evaluate the efficacy of dehydrated human amnion\/chorion membrane (EpiFix) allograft as an adjunct to multilayer compression therapy for the treatment of non\u2010healing full\u2010thickness venous leg ulcers. We randomly assigned 109 subjects to receive EpiFix and multilayer compression (\n                    <jats:italic>n<\/jats:italic>\n                    = 52) or dressings and multilayer compression therapy alone (\n                    <jats:italic>n<\/jats:italic>\n                    = 57). Patients were recruited from 15 centres around the USA and were followed up for 16 weeks. The primary end point of the study was defined as time to complete ulcer healing. Participants receiving weekly application of EpiFix and compression were significantly more likely to experience complete wound healing than those receiving standard wound care and compression (60% versus 35% at 12 weeks,\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b70128, and 71% versus 44% at 16 weeks,\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b70065). A Kaplan\u2013Meier analysis was performed to compare the time\u2010to\u2010healing performance with or without EpiFix, showing a significantly improved time to healing using the allograft (log\u2010rank\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b70110). Cox regression analysis showed that subjects treated with EpiFix had a significantly higher probability of complete healing within 12 weeks (HR: 2\u00b726, 95% confidence interval 1\u00b725\u20134\u00b710,\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b701) versus without EpiFix. These results confirm the advantage of EpiFix allograft as an adjunct to multilayer compression therapy for the treatment of non\u2010healing, full\u2010thickness venous leg ulcers.\n                  <\/jats:p>","DOI":"10.1111\/iwj.12843","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T01:52:38Z","timestamp":1507686758000},"page":"114-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["A multicentre randomised controlled trial evaluating the efficacy of dehydrated human amnion\/chorion membrane (EpiFix\n                    <sup>\u00ae<\/sup>\n                    ) allograft for the treatment of venous leg ulcers"],"prefix":"10.1111","volume":"15","author":[{"given":"Christian","family":"Bianchi","sequence":"first","affiliation":[{"name":"Department of Surgery Loma Linda University Medical Center  Loma Linda CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Cazzell","sequence":"additional","affiliation":[{"name":"Limb Preservation Platform, Inc  Fresno CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Vayser","sequence":"additional","affiliation":[{"name":"ILD Research Center  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M","family":"Reyzelman","sequence":"additional","affiliation":[{"name":"Center for Clinical Research, Inc  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Dosluoglu","sequence":"additional","affiliation":[{"name":"VA Western New York Healthcare System  Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Tovmassian","sequence":"additional","affiliation":[{"name":"Center for Clinical Research, Inc. Sacramento Foot and Ankle Center  Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EpiFix VLU Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12102"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4471-0473-5","volume-title":"Chronic venous insufficiency. Diagnosis and treatment","author":"Ballard JL","year":"2000"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.121128"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2014.903258"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra055289"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00250.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70134-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.049"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00174.x"},{"key":"e_1_2_6_11_1","first-page":"341","volume-title":"Venous leg ulcers","author":"McLafferty RB","year":"2014"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1001\/archderm.1997.03890460053006","article-title":"Initial rate of healing predicts complete healing of venous ulcers","volume":"133","author":"Tallman P","year":"1997","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2015.24.11.530"},{"issue":"9","key":"e_1_2_6_14_1","first-page":"242","article-title":"An evidence\u2010based algorithm for treating venous leg ulcers utilizing the Cochrane database of systematic reviews","volume":"25","author":"Kimmel HM","year":"2013","journal-title":"Wounds"},{"issue":"2","key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00000658-197302000-00003","article-title":"The effect of human amniotic membranes on the bacteria population of infected rat burns","volume":"177","author":"Robson MC","year":"1973","journal-title":"Ann Surg"},{"issue":"6","key":"e_1_2_6_16_1","first-page":"904","article-title":"Amniotic membranes as a temporary wound dressing","volume":"136","author":"Robson MC","year":"1973","journal-title":"Surg Gynecol Obstet"},{"issue":"9","key":"e_1_2_6_17_1","first-page":"1468","article-title":"Human amniotic membranes for burns","volume":"75","author":"Ninman C","year":"1975","journal-title":"Am J Nurs"},{"issue":"4","key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/00006534-198010000-00017","article-title":"Comparison of the bacterial clearing effects of different biologic dressings on granulating wounds following thermal injury","volume":"66","author":"Salisbury RE","year":"1980","journal-title":"Plast Reconstr Surg"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198212000-00009"},{"issue":"10","key":"e_1_2_6_20_1","first-page":"299","article-title":"Scientific and clinical support for the use of dehydrated amniotic membrane in wound management","volume":"24","author":"Fetterolf DE","year":"2012","journal-title":"Wounds"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33141"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-824X-6-10"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12097"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12395"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12566"},{"issue":"1","key":"e_1_2_6_26_1","first-page":"10","article-title":"Wound care outcomes and associated cost among patients treated in US outpatient wound centers: data from the US Wound Registry","volume":"24","author":"Fife CE","year":"2012","journal-title":"Wounds"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12227"},{"key":"e_1_2_6_28_1","volume-title":"Chronic venous ulcers: a comparative effectiveness review of treatment modalities","author":"Zenilman J","year":"2013"},{"issue":"1","key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1258\/026835503321236858","article-title":"The clinical and histological effects of Dermagraft\u00ae in the healing of chronic venous leg ulcers","volume":"18","author":"Krishnamoorthy L","year":"2003","journal-title":"Phlebology"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12053"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1998.tb02510.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12156"},{"key":"e_1_2_6_33_1","unstructured":"Organogenesis Inc.. Apligraf [WWW document]. URLhttp:\/\/www.apligraf.com\/professional\/pdf\/prescribing_information.pdf[accessed on 12 July 2017]."},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33265"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:22:44Z","timestamp":1695558164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,11]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/iwj.12843"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12843","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,11]]},"assertion":[{"value":"2017-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}