{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:45:48Z","timestamp":1788788748175,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002630","name":"Ewha Womans University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002630","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Various types of skin substitutes composed of fibroblasts and\/or keratinocytes have been used for the treatment of diabetic ulcers. However, the effects have generally not been very dramatic. Recently, human umbilical cord blood\u2010derived mesenchymal stromal cells (hUCB\u2010MSCs) have been commercialised for cartilage repair as a first cell therapy product using allogeneic stem cells. In a previous pilot study, we reported that hUCB\u2010MSCs have a superior wound\u2010healing capability compared with fibroblasts. The present study was designed to compare the treatment effect of hUCB\u2010MSCs with that of fibroblasts on the diabetic wound healing in vitro. Diabetic fibroblasts were cocultured with healthy fibroblasts or hUCB\u2010MSCs. Five groups were evaluated: group I, diabetic fibroblasts without coculture; groups II and III, diabetic fibroblasts cocultured with healthy fibroblasts or hUCB\u2010MSCs; and groups IV and V, no cell cocultured with healthy fibroblasts or hUCB\u2010MSCs. After a 3\u2010day incubation, cell proliferation, collagen synthesis levels and glycosaminoglycan levels, which are the major contributing factors in wound healing, were measured. As a result, a hUCB\u2010MSC\u2010treated group showed higher cell proliferation, collagen synthesis and glycosaminoglycan level than a fibroblast\u2010treated group. In particular, there were significant statistical differences in collagen synthesis and glycosaminoglycan levels (<jats:italic>P<\/jats:italic> = 0\u00b7029 and <jats:italic>P<\/jats:italic> = 0\u00b7019, respectively). In conclusion, these results demonstrate that hUCB\u2010MSCs may have a superior effect to fibroblasts in stimulating diabetic wound healing.<\/jats:p>","DOI":"10.1111\/iwj.12849","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T04:08:32Z","timestamp":1510114112000},"page":"133-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Comparison of human umbilical cord blood\u2010derived mesenchymal stem cells with healthy fibroblasts on wound\u2010healing activity of diabetic fibroblasts"],"prefix":"10.1111","volume":"15","author":[{"given":"Jae\u2010A","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Don","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Korea 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