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The study was conducted in a vascular surgery service, including outpatient wound clinic and inpatient ward, in a tertiary care academic centre. In total, 70 patients with vasculopathy and lower\u2010extremity wounds of mixed aetiology were enrolled in the trial; 68 completed the study. Patients were randomised to receive LFCUD plus usual care (<jats:italic>n<\/jats:italic>= 33) or usual care (<jats:italic>n<\/jats:italic>= 37) at 4 weekly visits, and were followed thereafter for up to 12 wk. The main outcome measures included closed wounds, change in wound surface area (WSA), and wound appearance by the revised Photographic Wound Assessment Tool (revPWAT). After 4 weekly LFCUD treatments, patients in the LFCUD group had significantly better wound appearance (total revPWAT score) compared with the control group treated only with usual care (<jats:italic>P<\/jats:italic>= &lt;0.05). LFCUD\u2010treated wounds also had a significant reduction in WSA over 4 wk that was not found in the UC group. LFCUD treatment was also associated with a greater number of healed wounds, odds ratio 5.00 (95% CI 1.24\u201020.25), and fewer instances of wound deterioration. Weekly LFCUD applications to patients with significant vasculopathy resulted in superior healing outcomes when compared with current usual wound care practice.<\/jats:p>","DOI":"10.1111\/iwj.12887","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T11:28:40Z","timestamp":1516015720000},"page":"460-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The effect of 22.5 kHz low\u2010frequency contact ultrasound debridement (LFCUD) on lower extremity wound healing for a vascular surgery population: A randomised controlled trial"],"prefix":"10.1111","volume":"15","author":[{"given":"Christine Anne","family":"Murphy","sequence":"first","affiliation":[{"name":"The Ottawa Hospital: Limb Preservation Program Ottawa Canada"},{"name":"Faculty of Health Rehabilitation Sciences Western University London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Houghton","sequence":"additional","affiliation":[{"name":"Faculty of Health Rehabilitation Sciences Western University London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Brandys","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital: Limb Preservation Program Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Rose","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital: Limb Preservation Program Ottawa Canada"},{"name":"Faculty of Health Rehabilitation Sciences Western University London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Bryant","sequence":"additional","affiliation":[{"name":"Faculty of Health Rehabilitation Sciences Western University London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/ccd.23373","article-title":"The management of patients with peripheral artery disease (updating the 2005 guideline): a report of the American College of Cardiology Foundation\/American Heart Association task force on practice guidelines: developed in collaboration with the Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society for Vascular Medicine, and Society for Vascular Surgery","volume":"79","author":"Hirsch AT","year":"2012","journal-title":"Catheter Cardiovasc Interv"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.11.1317"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-11-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.19.2570"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-7560(200009\/10)16:1 <::AID-DMRR139>3.0.CO;2-8"},{"key":"e_1_2_8_7_1","unstructured":"Canadian Diabetes Association. 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