{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:26:38Z","timestamp":1783463198739,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T00:00:00Z","timestamp":1524355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001765","name":"Musculoskeletal Transplant Foundation","doi-asserted-by":"publisher","award":["DFU\u201001"],"award-info":[{"award-number":["DFU\u201001"]}],"id":[{"id":"10.13039\/100001765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Aseptically processed human reticular acellular dermal matrix (HR\u2010ADM) has been previously shown to improve wound closure in 40 diabetic patients with non\u2010healing foot ulcers. The study was extended to 40 additional patients (80 in total) to validate and extend the original findings. The entire cohort of 80 patients underwent appropriate offloading and standard of care (SOC) during a 2\u2010week screening period and, after meeting eligibility criteria, were randomised to receive weekly applications of HR\u2010ADM plus SOC or SOC alone for up to 12 weeks. The primary outcome was the proportion of wounds closed at 6 weeks. Sixty\u2010eight percent (27\/40) in the HR\u2010ADM group were completely healed at 6 weeks compared with 15% (6\/40) in the SOC group. The proportions of wounds healed at 12 weeks were 80% (34\/40) and 30% (12\/40), respectively. The mean time to heal within 12 weeks was 38 days for the HR\u2010ADM group and 72 days for the SOC group. There was no incidence of increased adverse or serious adverse events between groups or any graft\u2010related adverse events. The mean and median HR\u2010ADM product costs at 12 weeks were $1200 and $680, respectively. HR\u2010ADM is clinically superior to SOC, is cost effective relative to other comparable treatment modalities, and is an efficacious treatment for chronic non\u2010healing diabetic foot ulcers.<\/jats:p>","DOI":"10.1111\/iwj.12920","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T05:26:48Z","timestamp":1524461208000},"page":"731-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["An aseptically processed, acellular, reticular, allogenic human dermis improves healing in diabetic foot ulcers: A prospective, randomised, controlled, multicentre follow\u2010up trial"],"prefix":"10.1111","volume":"15","author":[{"given":"Charles M","family":"Zelen","sequence":"first","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P","family":"Orgill","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E","family":"Serena","sequence":"additional","affiliation":[{"name":"Serena Group  Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E","family":"Galiano","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery; Feinberg School of Medicine Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa J","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions, Inc.  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