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An octenidine\u2010based hydrogel has been shown to modulate immunological function in an in vitro wound model, suggesting an improved scar formation. In this prospective, randomised, observer\u2010blinded, and intra\u2010patient\u2010controlled study, 45 patients who underwent abdominoplasty or mastectomy with transverse rectus abdominis muscle (TRAM) flap reconstruction were given both a standard postoperative wound dressing on one wound side and an octenidine\u2010based hydrogel with transparent film dressing, covered with standard postoperative dressing on the other side. Four instances of hypertrophia were reported in the gel side versus 12 in the standard dressing side. Visual Analogue Scale (VAS) pain scores taken during postoperative dressing changes showed reduced scores on the gel side at all time points. Vancouver Scar Scale (VSS) scores showed improvement in the gel side at 3, 6, and 12\u2009months postoperatively. Skin distensibility measured using a cutometer showed significantly improved measures in gel\u2010treated wounds, similar to measures of healthy skin. Trans\u2010epidermal water loss (TEWL), measured using a tewameter, showed improved values on the gel side soon after surgery, with both the control and the gel side normalising after approximately 6 months. The octenidine\u2010based wound dressing demonstrates improved wound healing associated with a lower incidence of hypertrophic scar formation.<\/jats:p>","DOI":"10.1111\/iwj.12944","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T07:35:28Z","timestamp":1530257728000},"page":"914-920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["An intra\u2010individual surgical wound comparison shows that octenidine\u2010based hydrogel wound dressing ameliorates scar appearance following abdominoplasty"],"prefix":"10.1111","volume":"15","author":[{"given":"Johannes","family":"Matiasek","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery St. Josef Hospital  Vienna Austria"},{"name":"Department of Plastic, Aesthetic and Reconstructive Surgery Wilhelminen Hospital  Vienna 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