{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:11:37Z","timestamp":1791598297600,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001765","name":"Musculoskeletal Transplant Foundation","doi-asserted-by":"publisher","award":["002"],"award-info":[{"award-number":["002"]}],"id":[{"id":"10.13039\/100001765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Amnion and chorion allografts have shown great promise in healing diabetic foot ulcers (DFUs). Results from an interim analysis of 40 patients have demonstrated the accelerated healing ability of a novel aseptically processed, dehydrated human amnion and chorion allograft (dHACA). The goal of this study was to report on the full trial results of 80 patients where dHACA was compared with standard of care (SOC) in achieving wound closure in non\u2010healing DFUs. After a 2\u2010week screening period, during which patients with DFUs were unsuccessfully treated with SOC, patients were randomised to either SOC alone or SOC with dHACA applied weekly for up to 12\u2009weeks. At 12\u2009weeks, 85% (34\/40) of the dHACA\u2010treated DFUs healed, compared with 33% (13\/40) treated with SOC alone. Mean time to heal within 12\u2009weeks was significantly faster for the dHACA\u2010 treated group compared with SOC, 37\u2009days vs 67\u2009days in the SOC group (<jats:italic>P<\/jats:italic>\u2009=\u2009.000006). Mean number of grafts used per healed wound during the same time period was 4.0, and mean cost of the tissue to heal a DFU was $1771. The authors concluded that aseptically processed dHACA heals DFUs significantly faster than SOC at 12\u2009weeks.<\/jats:p>","DOI":"10.1111\/iwj.12954","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:03:19Z","timestamp":1531958599000},"page":"950-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Use of an aseptically processed, dehydrated human amnion and chorion membrane improves likelihood and rate of healing in chronic diabetic foot ulcers: A prospective, randomised, multi\u2010centre clinical trial in 80 patients"],"prefix":"10.1111","volume":"15","author":[{"given":"Lawrence A","family":"DiDomenico","sequence":"first","affiliation":[{"name":"Lower Extremity Institute for Research and Therapy  Youngstown Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P","family":"Orgill","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D","family":"Galiano","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Feinberg School of Medicine, Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E","family":"Serena","sequence":"additional","affiliation":[{"name":"Serena Group  Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa J","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions, Inc.  Cody Wyoming"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarrod P","family":"Kaufman","sequence":"additional","affiliation":[{"name":"General Surgery Premier Surgical  Brick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J","family":"Young","sequence":"additional","affiliation":[{"name":"Martinsville Research Institute  Martinsville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen M","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Allen M Jacobs and Associates  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-7056","authenticated-orcid":false,"given":"Charles M","family":"Zelen","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CWCMR.S84990"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13054"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0491-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0651"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1913.04340130021008"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v015a07"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.09.009"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001095"},{"key":"e_1_2_5_13_1","first-page":"40","article-title":"A cross\u2010sectional validation study of using NERDS and STONEES to assess bacterial burden","volume":"55","author":"Woo KY","year":"2009","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1879"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.004"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12600"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12566"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0645"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12357"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12329"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2009.00585.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.290"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1701"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200506000-00012"},{"issue":"7","key":"e_1_2_5_25_1","first-page":"184","article-title":"A prospective comparison of diabetic foot ulcers treated with either a cryopreserved skin allograft or a bioengineered skin substitute","volume":"23","author":"DiDomenico L","year":"2011","journal-title":"Wounds"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T08:16:28Z","timestamp":1694852188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,17]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/iwj.12954"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12954","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,17]]},"assertion":[{"value":"2018-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}