{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:01:26Z","timestamp":1781665286231,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,5]],"date-time":"2018-08-05T00:00:00Z","timestamp":1533427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Gram\u2010negative germs with and without multi\u2010resistance are garnering more and more importance. The aim of this study was to investigate the frequency and rate of resistance against antibiotics and to clarify the impact of Gram\u2010negative bacteria, especially with high rates of resistance, for the treatment of venous leg ulcers. This is a retrospective, monocentric, non\u2010randomised open study. Included were all data within 1 year of bacterial swabs of venous leg ulcers. We performed summarization, pooling, and descriptive analysis for frequencies and crossover. We analysed 679 swabs of 285 patients with venous leg ulcers. The mean patient age was 69.78 years. There were 76.1% Gram\u2010positive and 58.2% Gram\u2010negative germs detected; 56.5% of the swabs showed multi\u2010resistance. Gram\u2010negative bacteria were associated with more pain. Exacerbation and relevant aggravation of wounds that led to stationary treatment occurred more frequently. With polihexanid treatment, we saw less Gram\u2010negative flora. This study showed an immediate impact of Gram\u2010negative germs on the patient's pain, the risk for aggravation, and the choice of treatment. Further studies for prophylaxis and treatment of Gram\u2010negative germs in venous leg ulcer therapy are needed.<\/jats:p>","DOI":"10.1111\/iwj.12955","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T07:40:25Z","timestamp":1533627625000},"page":"958-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Gram\u2010negative bacteria on the treatment of venous leg ulcers"],"prefix":"10.1111","volume":"15","author":[{"given":"Wibke L","family":"Engelberg","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie, Venerologie und Allergologie Ruhr\u2010Universit\u00e4t Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"D\u00f6rler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie, Venerologie und Allergologie Ruhr\u2010Universit\u00e4t Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"St\u00fccker","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie, Venerologie und Allergologie Ruhr\u2010Universit\u00e4t Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Reich\u2010Schupke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie, Venerologie und Allergologie Ruhr\u2010Universit\u00e4t Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,5]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Expertenstandard \u2018Pflege von Menschen mit chronischen Wunden \u2013 1. Aktualisierung 2015\u2019","author":"Deutsches Netzwerk f\u00fcr Qualit\u00e4tsentwicklung in der Pflege (Hrsg.)","year":"2015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07535.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-003-0535-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12387"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1622259"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32833f0d3e"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1621786"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.07.013"},{"key":"e_1_2_7_10_1","unstructured":"Nationales Referenzzentrum f\u00fcr Surveillance von nosokomialen Infektionen. Surveillance der Antibiotikaanwendung und der bakteriellen Resistenzen auf Intensivstationen (SARI).http:\/\/sari.eu-burden.info. Accessed November 13 2013."},{"key":"e_1_2_7_11_1","first-page":"A1570","article-title":"Rasanter Wandel der Erreger","volume":"107","author":"Siegmund\u2010Schultze N","year":"2010","journal-title":"Deutsches \u00c4rzteblatt"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1754"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181e6cbc5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01036.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12540"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.2967"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000445952.83084.a0"},{"key":"e_1_2_7_18_1","unstructured":"H Lode 2008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/422997"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/253947"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01153.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/604713"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2010.01.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.12687\/phleb2350-2-2017"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv331"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2013.0113"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2013.2198"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2015.24.3.121"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-013-2635-9"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04110.x"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T08:16:31Z","timestamp":1694852191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,5]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/iwj.12955"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12955","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,5]]},"assertion":[{"value":"2018-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}