{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:22:35Z","timestamp":1773307355233,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Fund of Hubei Ministry of Education","award":["B2016131"],"award-info":[{"award-number":["B2016131"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>The goal of this study was to evaluate the effect of hydrogen sulphide on inflammatory factors and the energy metabolism of mitochondria after limb reperfusion injury in rats. Sixty Wistar rats were divided into three groups: the sham operated group, the control group (the ischaemia\u2010reperfusion injury [IRI]\u2009+\u2009normal saline group), and the experimental group (the IRI\u2009+\u2009H<jats:sub>2<\/jats:sub>S group). An experimental rat model of limb IRI was established. Skeletal muscle samples were collected to observe the content of necrotic products (including myoglobin (MB), lysophosphatidylcholine (LPC), and lipid peroxidation (LPO)); blood samples were collected to observe changes in the contents of interleukin\u20101 (IL\u20101), Interleukin\u20106 (IL\u20106), and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1); and the mitochondria of skeletal muscle cells were extracted for mitochondrial transmembrane potential measurement and adenosine triphosphate (ATP) content determination. The results underwent further statistical analysis. The contents of MB, LPC, and LPO in the limb skeletal muscle, liver, lung, and kidney tissues of rats in the control group were significantly increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) after IRI, which was markedly attenuated by treatment with hydrogen sulphide (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Ischaemia\/reperfusion of the lower extremities in rats triggered a significant increase in serum levels of IL\u20101, IL\u20106, and TNF\u2010\u03b1, which was significantly inhibited by treatment with H<jats:sub>2<\/jats:sub>S during ischaemia\/reperfusion. In addition, the inhibitory effect tended to be time\u2010dependent. After limb ischaemia\/reperfusion, the mitochondrial transmembrane potential of skeletal muscle cells in the control group decreased significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), while the potential energy of the mitochondrial membrane in the experimental group was significantly higher than that in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The content of ATP in mitochondria of skeletal muscle cells of ischaemia\u2010reperfusion rats in the control group was significantly lower than that in the sham operated group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), while the content of ATP of mitochondria in the experimental group after H<jats:sub>2<\/jats:sub>S treatment was significantly higher than the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Hydrogen sulphide can alleviate the injury of skeletal muscle and distal organs after limb ischaemia\u2010reperfusion and reduce local inflammatory reaction, which is essential in alleviating mitochondrial transmembrane potential and energy metabolism disorder during reperfusion injury. The purpose of the study is to summarise the available information and provide theoretical support for the application of hydrogen sulphide in the treatment of limb IRI in skeletal muscle and distal organs.<\/jats:p>","DOI":"10.1111\/iwj.13068","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T07:05:20Z","timestamp":1548745520000},"page":"595-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["RETRACTED: Effect of hydrogen sulphide on inflammatory factors of the mitochondria after limb ischaemia\u2010reperfusion injury in rats"],"prefix":"10.1111","volume":"16","author":[{"given":"Jun","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Renmin Hospital Hubei University of Medicine  Shiyan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010Hua","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Microscopic Orthopaedic, Renmin Hospital Hubei University of Medicine  Shiyan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Renmin Hospital Hubei University of Medicine  Shiyan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4612"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5869"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.118"},{"key":"e_1_2_8_5_1","first-page":"410","article-title":"H(2)S protecting against lung injury following limb ischemia\u2010reperfusion 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