{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:46:15Z","timestamp":1788824775664,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>This study was undertaken to evaluate the diagnostic and prognostic values of pentraxin\u20103 (PTX\u20103) in patients with infected diabetic foot ulcers (IDFU) as well as to assess the association between PTX\u20103 levels and IDFU severity. This study included 60 IDFU patients (Group 1), 45 diabetic patients without DFU (Group 2), and 45 healthy controls. Patients with IDFU were divided into mild, moderate, and severe subgroups based on classification of clinical severity. Patients who underwent amputation were also documented. Blood samples were collected to determine PTX\u20103 levels. PTX\u20103 levels in healthy controls, Group 1, and Group 2 were 5.83 (3.41\u201020) ng\/mL, 1.47 (0.61\u201015.13) ng\/mL, and 3.26 (0.67\u201020) ng\/mL, respectively. A negative correlation between plasma PTX\u20103 and glucose levels was found. There were significant differences in terms of procalcitonin (PCT) and PTX\u20103 levels in the subgroup analysis of Group 1. The PTX\u20103 level in patients who did or did not undergo amputation was 4.1 (0.8\u201013.7) and 1 (0.6\u201015.1) ng\/mL, respectively. Results suggest that PTX\u20103 is a particularly effective marker in patients with IDFU, both in terms of predicting disease severity and assisting in the decision to perform amputation.<\/jats:p>","DOI":"10.1111\/iwj.13075","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T08:19:27Z","timestamp":1550218767000},"page":"659-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Pentraxin\u20103: A new parameter in predicting the severity of diabetic foot infection?"],"prefix":"10.1111","volume":"16","author":[{"given":"Safak","family":"Ozer Balin","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Sagmak Tartar","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and 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