{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:56:17Z","timestamp":1791622577626,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Abnormal, persistent inflammation after bypass surgery could prevent healing of an ischaemic foot lesion. In 37 patients with peripheral arterial disease (PAD) (Rutherford Grade III Category 5) who underwent infrapopliteal vein graft and midfoot amputation, plasma levels of fibrinogen, C\u2010reactive protein (CRP), interleukin\u20101 (IL\u20101), interleukin\u20106 (IL\u20106), tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and matrix metalloproteinase\u20102 and \u20109 (MMP\u20102 and MMP\u20109) were determined preoperatively and during the follow up. Nine patients without clinical and Doppler evidence of arterial disease, who underwent post\u2010traumatic midfoot primary amputation, were included in the experiment group, and 15 age\u2010matched healthy volunteers served as control. In patients who had midfoot amputation for trauma, all wounds healed. Seven (19%) wounds in patients with an occluded graft healed, and five (13%) required major amputation because of a non\u2010healing wound. Time required for complete healing of the lesion was similar between trauma and PAD patients (8\u2009\u00b1\u20092\u2009months vs 11\u2009\u00b1\u20096, respectively, <jats:italic>P<\/jats:italic>\u2009=\u2009NS). Univariate analysis demonstrated that, in PAD patients, the postoperative high levels of TNF\u2010\u03b1, IL\u20106, and MMP\u20102 and \u20109 were predictive for wound healing failure at 3, 6, and 9 months (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), respectively. Furthermore, the subgroup of patients who experienced occlusion of the vein graft during follow up had a significant increase of MMP\u20102, \u20109, IL\u20106, and TNF\u2010\u03b1 at 3, 6, and 9 months (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), respectively. Monitoring inflammatory markers allows the determination of patients at risk of healing failure of midfoot amputation after distal revascularisation and might predict the fate of the vein graft.<\/jats:p>","DOI":"10.1111\/iwj.13086","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T01:48:51Z","timestamp":1550454531000},"page":"716-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Inflammatory biomarkers, vascular procedures of lower limbs, and wound healing"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-7930","authenticated-orcid":false,"given":"Paolo","family":"Sapienza","sequence":"first","affiliation":[{"name":"Department of General and Plastic Surgery \u201cPietro Valdoni\u201d \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mingoli","sequence":"additional","affiliation":[{"name":"Emergency Department \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine \u201cSapienza\u201d, University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioia","family":"Brachini","sequence":"additional","affiliation":[{"name":"Department of General and Plastic Surgery \u201cPietro Valdoni\u201d \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Biacchi","sequence":"additional","affiliation":[{"name":"Department of General and Plastic Surgery \u201cPietro Valdoni\u201d \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio V.","family":"Sterpetti","sequence":"additional","affiliation":[{"name":"Department of General and Plastic Surgery \u201cPietro Valdoni\u201d \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Grande","sequence":"additional","affiliation":[{"name":"Department of General and Plastic Surgery \u201cPietro Valdoni\u201d \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University \u201cMagna Graecia\u201d, Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Centre Hospitalier Sud Francilien  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12329"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12162"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02133411"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.05.001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(11)60009-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303849"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.2.513.513"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/1043-4666(92)90079-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(03)00065-9"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.02.022"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.02.008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12464"},{"key":"e_1_2_5_14_1","first-page":"41","volume-title":"Rutherford Vascular Surgery","author":"Dayal R","year":"2005"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2017.07.018"},{"key":"e_1_2_5_16_1","unstructured":"American Society of Anesthesiologists. 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