{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:28:18Z","timestamp":1785875298904,"version":"3.56.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2018R1D1A1B07050442"],"award-info":[{"award-number":["2018R1D1A1B07050442"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Numerous studies have demonstrated the various medicinal properties of <jats:styled-content style=\"fixed-case\"><jats:italic>Panax ginseng<\/jats:italic><\/jats:styled-content>, including angiogenic, immuno\u2010stimulating, antimicrobial, and anti\u2010inflammatory activities, which can be helpful in chronic wound healing. However, a direct role for <jats:styled-content style=\"fixed-case\"><jats:italic>P. ginseng<\/jats:italic><\/jats:styled-content> in chronic wound healing has not been demonstrated. The present study was designed to evaluate the effects of <jats:styled-content style=\"fixed-case\"><jats:italic>P. ginseng<\/jats:italic><\/jats:styled-content> extract on diabetic fibroblasts in vitro. Human diabetic fibroblasts were cultured in the presence of Ginsenoside Rb1 (G\u2010Rb1), the active component in <jats:styled-content style=\"fixed-case\"><jats:italic>P. ginseng<\/jats:italic><\/jats:styled-content> (10 ng\/mL), and untreated diabetic fibroblasts were used as controls. Cell proliferation, collagen synthesis, the production of various growth factors (basic fibroblast growth factor [bFGF]; vascular endothelial growth factor [VEGF]; and transforming growth factor\u2010\u03b21 [TGF\u2010\u03b21]), and the synthesis of matrix metalloproteinase 1 (MMP\u20101) and tissue inhibitor of metalloproteinases 1 (TIMP\u20101) were compared using enzyme\u2010linked immunosorbent assay and immunofluorescence staining. Compared with the control group, G\u2010Rb1\u2010treated fibroblasts showed significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) higher levels of cell proliferation, collagen synthesis, VEGF, TGF\u2010\u03b21, and TIMP\u20101. However, no significant differences in bFGF and MMP\u20101 levels were observed between the two groups. These results suggest that <jats:styled-content style=\"fixed-case\"><jats:italic>P. ginseng<\/jats:italic><\/jats:styled-content> treatment may stimulate the wound\u2010healing activity of diabetic fibroblasts in vitro.<\/jats:p>","DOI":"10.1111\/iwj.13091","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T06:32:04Z","timestamp":1549607524000},"page":"737-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of <i>Panax ginseng<\/i> extract on the activity of diabetic fibroblasts in vitro"],"prefix":"10.1111","volume":"16","author":[{"given":"Sik","family":"Namgoong","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2875-9276","authenticated-orcid":false,"given":"Seung\u2010Kyu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyup\u2010Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Kangwon National University College of Medicine  Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Sang","family":"Dhong","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1539","article-title":"Panax ginseng","volume":"68","author":"Kiefer D","year":"2003","journal-title":"Am. 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