{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:00:02Z","timestamp":1790564402434,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>The overall quality of evidence of autologous platelet\u2010rich plasma (PRP) for treating chronic wounds remains low. While further well\u2010designed clinical studies are clearly required to convincingly demonstrate the efficacy of autologous PRP in improved healing of venous leg ulcers (VLUs) and other chronic wounds, there is also an increasing need to better define the underlying mechanisms of action and whether positive outcomes can be predicted based on the analysis of PRP. This brief review will discuss the current understanding of autologous PRP in VLUs and whether molecular evaluation of PRP at the time of collection could potentially be informative to clinical outcomes. Benefits of the autologous PRP treatment strategy include that PRP is easily accessible and is relatively inexpensive and safe. Better understanding of the mechanisms involved could improve treatment, enable supplementation, and\/or lead to gains in product development. Analysis of PRP could also add value to future clinical trials on efficacy and potentially personalised treatment regimens.<\/jats:p>","DOI":"10.1111\/iwj.13098","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T01:38:44Z","timestamp":1552441124000},"page":"788-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Autologous platelet\u2010rich plasma for healing chronic venous leg ulcers: Clinical efficacy and potential mechanisms"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-1060","authenticated-orcid":false,"given":"Carolina D.","family":"Weller","sequence":"first","affiliation":[{"name":"School of Nursing and Midwifery Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology and Therapeutics, John Curtin School of Medical Research Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane F.","family":"Arthur","sequence":"additional","affiliation":[{"name":"Australian Centre for Blood Diseases Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Southey","sequence":"additional","affiliation":[{"name":"Precision Medicine Monash University  Melbourne Victoria Australia"},{"name":"Cancer Epidemiology and Intelligence Division Cancer Council Victoria  Melbourne Victoria Australia"},{"name":"Department of Clinical Pathology The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Australian Centre for Blood Diseases Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1902","article-title":"Venous leg ulcers","volume":"2016","author":"Nelson EA","year":"2016","journal-title":"BMJ Clin Evid"},{"issue":"5","key":"e_1_2_7_3_1","first-page":"331","article-title":"Venous leg ulcer management in general practice\u2014practice nurses and evidence based guidelines","volume":"41","author":"Weller C","year":"2012","journal-title":"Aust Fam Physician"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"4","article-title":"The prevalence and incidence of chronic wounds: a literature review","volume":"22","author":"Graves N","year":"2014","journal-title":"Wound Pract Res"},{"key":"e_1_2_7_5_1","first-page":"CD000265","article-title":"Compression for venous leg ulcers","volume":"11","author":"O'Meara S","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1428739"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-742676"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"issue":"3","key":"e_1_2_7_9_1","first-page":"99","article-title":"Comparison of the effects of platelet\u2010rich plasma prepared in various forms on the healing of dermal wounds in rats","volume":"28","author":"Esat Duymus M","year":"2016","journal-title":"Wounds"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734615575829"},{"issue":"4","key":"e_1_2_7_11_1","first-page":"P25","article-title":"Autologous platelet gel: fad or savoir? 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