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If expression takes the form of acute vaso\u2010occlusive crisis, SCD is currently considered to be a chronic systemic pathology, primarily associated with vasculopathy and ischaemia\u2010reperfusion phenomena. The haemolytic aspect of the disease may be associated with endothelial dysfunctional complications, including leg ulcers, which are a classic spontaneous complication of major SCD. Their frequency, all aetiologies combined, varies considerably according to the series under consideration. Hydroxycarbamide has become the standard treatment for some SCD phenotypes, but has classically been described as one of the causes of leg ulcer. This causality is widely debated and is still difficult to establish because it is a specific complication of the disease. Comorbidity factors (eg, iron deficiency) are also often implicated as causal or aggravating factors so research into all the potential aetiologies of leg ulcers in a sickle cell patient must be exhaustive. We discuss the aetiologies of a leg ulcer in a patient treated by hydrocarbamide for major SCD. The imputation of the drug was established, followed by a marrow allograft in this patient.<\/jats:p>","DOI":"10.1111\/iwj.13115","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T21:13:33Z","timestamp":1553721213000},"page":"897-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Leg ulcer induced by hydroxycarbamide in sickle cell disease: What is the therapeutic impact?"],"prefix":"10.1111","volume":"16","author":[{"given":"Esaie","family":"Soya","sequence":"first","affiliation":[{"name":"Department of Vascular Medicine Grenoble University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Makowski","sequence":"additional","affiliation":[{"name":"Hematology Department Grenoble University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Blaise","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine Grenoble University Hospital  Grenoble France"},{"name":"UMR 1042\u2013HP2 INSERM and University Grenoble\u2010Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"La Dr\u00e9panocytose mise \u00e0 jour 2011. 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