{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:57:42Z","timestamp":1775869062992,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Immunological factors play important roles in the occurrence of hypertrophic scars. Imiquimod can be used as an immunosuppressive agent to regulate the function of T\u2010helper (Th) cell subsets Th1 and Th2. In this article, we explored the impact of imiquimod on scar hyperplasia through Th cells. A rabbit ear hypertrophic scar model was built. Four round wounds were cut in each rabbit's ears ventrally with a diameter of 1 cm and bilateral symmetry. All the right ear wounds were treated with 5% imiquimod cream. The blank control group contained all the left ear wounds, which were treated with Vaseline ointment at the same time. Haematoxylin and eosin and Masson staining showed that imiquimod collagen deposition was significantly reduced compared with the control group, scar index (SEI) showed that the proliferative degree reached its peak on the 28th day after operation in blank group, and the degree of hyperplasia was significantly higher than that of the imiquimod group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Real\u2010time Polymerase chain reaction results showed that the imiquimod induced the expression of Th2 cell\u2010related chemokines CCL2, CCL3, CCL5, CCL7, and CCL13 at each time point, which were significantly lower than that of the blank control group, and the expressions of Th1 cell\u2010associated chemokines CXCL10 and CXCL12 at each time point was significantly higher than the blank control group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Imiquimod can be used to regulate the expression of Th1 and Th2 cell\u2010associated chemokines to control scar hyperplasia.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13183","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T04:21:26Z","timestamp":1567398086000},"page":"1281-1288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Imiquimod regulating Th1 and Th2 cell\u2010related chemokines to inhibit scar hyperplasia"],"prefix":"10.1111","volume":"16","author":[{"given":"Baoguo","family":"Chen","sequence":"first","affiliation":[{"name":"Burs and Plastic Surgery The First Affiliate Hospital of PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huichao","family":"Li","sequence":"additional","affiliation":[{"name":"Burs and Plastic Surgery The First Affiliate Hospital of PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xia","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery The Former Fourth Military Medical Hospital  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.07.009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-178087"},{"issue":"7","key":"e_1_2_5_4_1","first-page":"1214","article-title":"Imiquimod inhibit scar formation in rabbit ear hypertrophic scar model","volume":"13","author":"Lun Y","year":"2013","journal-title":"Prog Mod 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