{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T20:44:56Z","timestamp":1785012296514,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to identify diabetic foot ulcer (DFU) patients at risk for the development of a hard\u2010to\u2010heal wound. This is a post\u2010hoc analysis of a prospective cohort study including a total of 208 patients with a DFU. The primary endpoints were time to healing and the development of a hard\u2010to\u2010heal\u2010wound. Univariable and multivariable logistic and Cox regression analysis were used to study the associations of patient characteristics with the primary endpoints. The number of previous DFUs [odds ratio (OR): 1.42, 95% confidence interval (CI): 1.01\u20101.99,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.04], University of Texas (UT) classification grade 2 (OR: 2.93, 95% CI: 1.27\u20106.72,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.01), UT classification grade 3 (OR: 2.80, 95% CI: 1.17\u20106.71,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.02), and a diagnosis of foot stand deformation (OR: 1.54, 95% CI: 0.77\u20103.08,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.05) were significantly associated with the development of a hard\u2010to\u2010heal wound. Only UT classification grade 3 (HR: 0.61, 95% CI: 0.41\u20100.90,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.01) was associated with time to healing. The number of previous DFUs, UT classification grade, and a diagnosis of foot deformation are significantly associated with development of a hard\u2010to\u2010heal wound in patients with a DFU. The only predictor significantly associated with time to healing was UT classification grade 3. These patient characteristics can be used to identify patients at risk for the development of hard\u2010to\u2010heal wounds, who might need an early intervention to prevent wound problems.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13194","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T08:12:42Z","timestamp":1565943162000},"page":"1339-1346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Outcome predictors for wound healing in patients with a diabetic foot ulcer"],"prefix":"10.1111","volume":"16","author":[{"given":"Maryam","family":"Mohammad Zadeh","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive, and Hand Surgery Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester","family":"Lingsma","sequence":"additional","affiliation":[{"name":"Department of Public Health, Center for Clinical Decision Making Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan W.","family":"van Neck","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, and Hand Surgery Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalibor","family":"Vasilic","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, and Hand Surgery Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Margreet","family":"van Dishoeck","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, and Hand Surgery Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S69520"},{"key":"e_1_2_6_3_1","unstructured":"World Health Organization.Global report on diabetes.2016."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S081"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl140"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v7.i18.449"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0940-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.03.033"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.464"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(00)00133-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2176"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2015.04.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13169-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.848"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-016-0111-0"},{"key":"e_1_2_6_16_1","unstructured":"vanDishoeckAM Mohammad ZadehM WeststrateKet al.A specialized paramedical triage team contributes to efficient care for diabetic foot ulcer patients. Paper presented at: BMJ International Forum on Quality and Safety in Healthcare; April 21\u201024 2015; London England."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12642"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12429"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1879"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177176"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.293.3473"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.7.1036"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2031"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.1.84"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00103-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0500500204"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.12.079"},{"key":"e_1_2_6_28_1","first-page":"41","article-title":"Prediction of wound healing in diabetic foot ulcers: an observational study in tertiary hospital in Indonesia","volume":"49","author":"Soewondo P","year":"2017","journal-title":"Acta Med Indones"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00698.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.08.108"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001500"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.13194","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:21:12Z","timestamp":1775866872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.13194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,16]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/iwj.13194"],"URL":"https:\/\/doi.org\/10.1111\/iwj.13194","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,16]]},"assertion":[{"value":"2019-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}