{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:57:24Z","timestamp":1775869044582,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Healing rates may not give a complete indication of the effectiveness and management of diabetic foot ulcers because of high recurrence rates. The most important outcome for patients is remaining ulcer\u2010free; however, this has hardly been investigated. The aim of our study was to prospectively investigate ulcer\u2010free survival days and ulcer healing in patients with diabetic foot ulcers. This was a prospective cohort study of all referrals to our diabetic foot expertise centre from December 2014 to April 2017. Outcomes were determined after a minimum follow\u2010up period of 12\u2009months. Primary outcomes were ulcer\u2010free survival days and 12\u2010month healing percentages. Predictors for ulcer\u2010free survival days and healing were investigated in multivariate analyses. A total of 158 patients were included. Median ulcer\u2010free survival days in the healed group were 233\u2009days (interquartile range [IQR] 121\u2010312) and 131\u2009days (IQR 0\u2013298) in the overall population. The healing rate at 12\u2010month follow up was 67% (106\/158), and the recurrence rate was 31% (33\/106). Independent predictors of ulcer\u2010free survival days were duration of diabetes, peripheral artery disease (PAD), cardiovascular disease, end\u2010stage renal disease (ESRD), and infection. Ulcer\u2010free survival days are related to PAD and cardiovascular disease, and ulcer\u2010free survival days should be the main outcome when comparing the effectiveness of management and prevention of the diabetic foot ulcers.<\/jats:p>","DOI":"10.1111\/iwj.13199","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T20:14:35Z","timestamp":1566245675000},"page":"1365-1372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ulcer\u2010free survival days and ulcer healing in patients with diabetic foot ulcers: A prospective cohort study"],"prefix":"10.1111","volume":"16","author":[{"given":"Afram","family":"Rumanes","sequence":"first","affiliation":[{"name":"Department of Surgery Ziekenhuisgroep Twente (ZGT)  Almelo and Hengelo The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap J.","family":"van 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