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In this case series, we describe a novel combination treatment method utilising small intestinal submucosa wound matrix (SISWM) with the bolster technique as a way of assisting the integration of collagen\u2010based wound treatment products into the base of complex wounds with the intent of restoring a dysfunctional extracellular matrix. In case 1, a 44\u2010year\u2010old female presented with an acute wound resulting from a spider bite to the posterior aspect of the right knee. In case 2, a 12\u2010year\u2010old male sustained multiple injuries to his right foot from an all\u2010terrain vehicle accident. In case 3, an 80\u2010year\u2010old female on anticoagulants sustained an avulsion injury to her left lower leg. In case 4, a 41\u2010year\u2010old female sustained a severe complex avulsion injury to the dorsal left forearm sustained from a dog bite. All patients were successfully treated with SISWM and the bolster technique, and their wounds healed completely within 6\u2009weeks. The bolster technique, when combined with an SISWM, is a novel method designed to enable the SISWM to impart its wound healing properties to these complex traumatic wounds. This case series presents treating clinicians with a different treatment methodology to assist the patient in achieving a successful outcome.<\/jats:p>","DOI":"10.1111\/iwj.13208","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T07:56:55Z","timestamp":1567411015000},"page":"1222-1229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The bolster technique utilising small intestinal submucosa wound matrix: A novel approach to wound treatment"],"prefix":"10.1111","volume":"16","author":[{"given":"Francis J.","family":"Collini","sequence":"first","affiliation":[{"name":"Renaissance Center for Plastic Surgery  Shavertown Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-8563","authenticated-orcid":false,"given":"Samantha C.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Cook Biotech Incorporated  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