{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:44:16Z","timestamp":1778899456607,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004143","name":"Society of University Surgeons Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long\u2010term treatment with AGE on cutaneous tissue perfusion. A total of 122 patients with Framingham Risk Score\u2009\u2265\u200910 were randomised in a double\u2010blinded manner to placebo or 2400\u2009mg AGE daily for 1 year and monitored. Cutaneous microcirculation was measured at 0 and 12\u2009months using laser Doppler velocimetry. A repeated measures analysis of variance (ANOVA) with a Greenhouse\u2013Geisser correction determined that mean post\u2010occlusive reactive hyperaemia differed significantly between time points. The mean percent change between the two time points 0 and 12\u2009months was 102, 64 (174, 15)% change for AGE and 78, 62 (107, 92)% change for the placebo group (\n                    <jats:italic>F<\/jats:italic>\n                    [1, 120] = 5. 95,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.016), 12\u2009months of AGE increases the microcirculation in patients with an increased risk for cardiovascular events estimated using the Framingham risk score. Increased microcirculation could hypothetically facilitate wound healing.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13220","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T10:03:47Z","timestamp":1568369027000},"page":"1487-1493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases: A double\u2010blinded placebo\u2010controlled study"],"prefix":"10.1111","volume":"16","author":[{"given":"Martine","family":"Wlosinska","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery and Transplantation, Clinical Sciences, Lund University Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann\u2010Christin","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery and Transplantation, Clinical Sciences, Lund University Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Hlebowicz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences, Lund University Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Malmsj\u00f6","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Clinical Sciences, Lund University Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Fakhro","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery and Transplantation, Clinical Sciences, Lund University Sk\u00e5ne University Hospital  Lund 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