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A literature appraisal described PAD treatment capacity to improve validated patient\u2010centred outcomes in controlled clinical studies. The PUBMED database was searched from 1 January 1970 to 21 June 2018, for original and derivative controlled clinical trial references addressing MeSH terms for \u2018ischemia\u2019 AND \u2018leg ulcer\u2019. Non\u2010ischemic ulcer treatment references were excluded. Frequencies of improved (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u2009.05) outcomes were reported. Eighty\u2010eight studies on 4153 patients were summarized. Walking, pain or QOL improved mainly for interventions administered before PAD became severe. Amputation incidence, pain and ulcer healing were more frequently reported in those with severe PAD. Independent of PAD severity, patients experienced more likely improved walking, QOL, or pain reduction in response to structured walking interventions or those increasing calf muscle activity. Those with more severe PAD were more likely to report amputation reduction, mainly in response to invasive interventions. Those with PAD experienced more consistently improved patient\u2010centred outcomes if they received multidisciplinary PAD management with supervised walking or calf muscle activity, with more likely amputation risk reduced for those with more severe PAD.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13232","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T19:04:11Z","timestamp":1570647851000},"page":"1521-1532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Peripheral arterial disease: Scoping review of patient\u2010centred outcomes"],"prefix":"10.1111","volume":"16","author":[{"given":"Laura","family":"Bolton","sequence":"first","affiliation":[{"name":"Department of Surgery Robert Wood Johnson University Hospital  New Brunswick New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-5-14"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.0446"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tvir.2016.04.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2013.12.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01110.2016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303849"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.07.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.11.1317"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12387"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"117","article-title":"Algorithm for prevention and therapy of calf ulcer","volume":"68","author":"Leskovec NK","year":"2014","journal-title":"Acta Med Croatica"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmv.2009.02.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.07.065"},{"issue":"11","key":"e_1_2_9_14_1","first-page":"28","article-title":"Diabetic foot ulcers\u2014effects on quality of life, costs, and mortality and the role of standard wound care and advanced\u2010care therapies in healing: a review","volume":"55","author":"Snyder RJ","year":"2009","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000453095.19109.5c"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003796"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.03.026"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439409"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000294"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(07)70215-X"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.142"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12533"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-013-2671-5"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.07.509"},{"issue":"11","key":"e_1_2_9_25_1","first-page":"32","article-title":"and the AAWC Government and Regulatory Task Force. 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