{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:35:15Z","timestamp":1768484115694,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the efficacy of intravenous lidocaine in relieving postoperative pain and promoting rehabilitation in laparoscopic colorectal surgery, we conducted this meta\u2010analysis. The systematic search strategy was performed on PubMed, EMBASE, Chinese databases, and Cochrane Library before September 2019. As a result, 10 randomised clinical trials were included in this meta\u2010analysis (<jats:italic>n<\/jats:italic> = 527 patients). Intravenous lidocaine significantly reduced pain scores at 2, 4, 12, 24, and 48\u2009hours on movement and 2, 4, and 12\u2009hours on resting\u2010state and reduced opioid requirement in first 24\u2009hours postoperatively (weighted mean difference [WMD] = \u22125.02 [\u22129.34, \u22120.70]; <jats:italic>P<\/jats:italic> = .02). It also decreased the first flatus time (WMD: \u221210.15 [\u221211.20, \u22129.10]; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.00001), first defecation time (WMD: \u221210.27 [\u221217.62, \u22122.92]; <jats:italic>P<\/jats:italic> = .006), length of hospital stay (WMD: \u22121.05 [\u22121.89, \u22120.21]; <jats:italic>P<\/jats:italic> = .01), and reduced the incidence of postoperative nausea and vomiting (risk ratio: 0.53 [0.30, 0.93]; <jats:italic>P<\/jats:italic> = .03) when compared with control group. However, it had no effect on pain scores at 24 and 48\u2009hours at rest, the normal dietary time, and the level of serum C\u2010reactive protein. In summary, perioperative intravenous lidocaine could alleviate acute pain, reduce postoperative analgesic requirements, and accelerate recovery of gastrointestinal function in patients undergoing laparoscopic colorectal surgery.<\/jats:p>","DOI":"10.1111\/iwj.13279","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T05:39:13Z","timestamp":1576301953000},"page":"351-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["RETRACTED: The effects of intravenous lidocaine on wound pain and gastrointestinal function recovery after laparoscopic colorectal surgery"],"prefix":"10.1111","volume":"17","author":[{"given":"Shi","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, West China Hospital Sichuan University  Chengdu 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