{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:49:28Z","timestamp":1791643768519,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"AVITA Medical"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Venous leg ulcers (VLUs) have a significant impact on approximately 3% of the adult population worldwide, with a mean NHS wound care cost of \u00a37600 per VLU over 12\u2009months. The standard care for VLUs is compression therapy, with a significant number of ulcers failing to heal with this treatment, especially with wound size being a risk factor for non\u2010healing. This multicentre, prospective, randomised trial evaluated the safety and effectiveness of autologous skin cell suspension (ASCS) combined with compression therapy compared with standard compression alone (Control) for the treatment of VLUs. Incidence of complete wound closure at 14\u2009weeks, donor site closure, pain, Health\u2010Related Quality of Life (HRQoL), satisfaction, and safety were assessed in 52 patients. At Week 14, VLUs treated with ASCS\u2009+\u2009compression had a statistically greater decrease in ulcer area compared with the Control (8.94\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    versus 1.23\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.0143). This finding was largely driven by ulcers &gt;10 to 80\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    in size, as these ulcers had a higher mean percentage of reepithelialization at 14\u2009weeks (ASCS\u2009+\u2009compression: 69.97% and Control: 11.07%,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.0480). Additionally, subjects treated with ASCS\u2009+\u2009compression experienced a decrease in pain and an increase in HRQoL compared with the Control. This study indicates that application of ASCS\u2009+\u2009compression accelerates healing in large venous ulcers.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13293","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:59:10Z","timestamp":1582765150000},"page":"742-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A pilot multi\u2010centre prospective randomised controlled trial of RECELL for the treatment of venous leg ulcers"],"prefix":"10.1111","volume":"17","author":[{"given":"Paul D.","family":"Hayes","sequence":"first","affiliation":[{"name":"St John's Innovation Centre  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith G.","family":"Harding","sequence":"additional","affiliation":[{"name":"Clinical Innovation Cardiff  Cardiff Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Doncaster Royal Infirmary  Doncaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"McCollum","sequence":"additional","affiliation":[{"name":"Wythenshawe Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"T\u00e9ot","sequence":"additional","affiliation":[{"name":"Lapeyronie Health Facility  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Mercer","sequence":"additional","affiliation":[{"name":"Bradford Royal Infirmary  Bradford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Russell","sequence":"additional","affiliation":[{"name":"Leeds General Infirmary  Leeds 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