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Recently, in an experimental study, we described an increase in keratinocyte proliferation after their exposition to quercetin plus oleic acid. In the present clinical study, we evaluated both the clinical efficacy and the safety of nano\u2010hydrogel embedded with quercetin and oleic acid in the treatment of lower limb skin wound in patients with diabetes mellitus (DM). Fifty\u2010six DM patients (28 men and 28 women, mean age 61.7\u2009\u00b1\u20099.2\u2009years) unsuccessfully treated with mechanical compression were enrolled and randomised to receive an add on treatment with hyaluronic acid (0.2%) or nano\u2010hydrogel embedded with quercetin and oleic acid. The treatment with nano\u2010hydrogel embedded with quercetin and oleic acid significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) reduced the wound healing time, in comparison to hyaluronic acid (0.2%) without developing of adverse drug reactions, suggesting that this formulation could be used in the management of wound healing even if other clinical trials must be performed in order to validate this observation.<\/jats:p>","DOI":"10.1111\/iwj.13299","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T01:54:25Z","timestamp":1577325265000},"page":"485-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Nano\u2010hydrogel embedded with quercetin and oleic acid as a new formulation in the treatment of diabetic foot ulcer: A pilot 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