{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:00:04Z","timestamp":1790564404634,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our aim was to compare the efficacy and safety of platelet\u2010rich plasma (PRP) application versus PRP injection for chronic venous leg ulcer (VLU) healing compared with compression therapy as a control. From July 2018 to December 2019, 90 chronic VLU patients were randomly assigned to PRP dressings (n = 30), local PRP injections (n = 30), and compression therapy alone (n = 30). Standard compression accompanied both PRP groups. The main endpoints were ulcer healing and area reduction within 3, 6, and 12\u2009months. Complications and ulcer recurrence were also recorded. The study included 72 (80.0%) males and 18 (20.0%) females aged 22 to 66\u2009years, having VLUs for 1 to 11\u2009years. PRP injection promoted healing (24\/30, 80%) more than PRP application (20\/30, 66.7%) and compression (14\/30, 46.7%), <jats:italic>P<\/jats:italic> =\u2009.007. Healing time was significantly shorter after PRP injection compared with the other two groups. A greater area reduction was observed after PRP injection compared with compression at all follow\u2010up visits, <jats:italic>P<\/jats:italic> =\u2009.013, .002, and &lt;\u2009.001, and compared with PRP application only at 3 months post\u2010treatment, <jats:italic>P<\/jats:italic> =\u2009.016. Recurrence and complications were comparable among the groups. PRP injection enhances the healing of chronic venous ulcers more than each of PRP application and compression therapy. All had comparable recurrence and safety.<\/jats:p>","DOI":"10.1111\/iwj.13361","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T03:25:59Z","timestamp":1586834759000},"page":"992-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Autologous platelet\u2010rich plasma injection enhances healing of chronic venous leg ulcer: A prospective randomised study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5328-018X","authenticated-orcid":false,"given":"Ahmed H.","family":"Elbarbary","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Tanta University Hospitals  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan A.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Tanta University Hospitals  Tanta 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