{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:37:41Z","timestamp":1791265061225,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) in treating diabetic foot ulcers (DFUs), we conducted both database searches (PubMed, MEDLINE, EMBASE, CENTRAL, and Web of Science) and reference searches for randomised controlled trials from the inception of databases to 30 January 2020. Two reviewers independently scrutinised the trials, extracted data, and assessed the quality of trials. The primary outcome was the proportion of complete healing. The secondary outcomes were mean time to complete healing and adverse events. A subgroup analysis was performed by different administration routes. Statistical analyses were performed in RevMan 5.3. The time to complete healing Kaplan\u2010Meier curves was pooled in the R software. Of the 156 citations, 9 trials (720 participants) met eligibility criteria and were included. The rhEGF achieved a higher complete healing rate than placebo (OR: 2.79, [95% CI: 1.99, 3.99]). The rhEGF also significantly shorten complete healing time (MD: \u221214.10\u2009days, [95% CI: \u221218.03, \u221210.16]). Subgroup analysis showed that topical application was superior to intralesional injection, but that may be because of different ulcer severity they included. No significant difference was shown in adverse events. Results were coherent with sensitivity analyses. Therefore, rhEGF is an effective and safe treatment for DFUs.<\/jats:p>","DOI":"10.1111\/iwj.13377","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T05:44:11Z","timestamp":1588052651000},"page":"1062-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy and safety of recombinant human epidermal growth factor for diabetic foot ulcers: A systematic review and meta\u2010analysis of randomised controlled trials"],"prefix":"10.1111","volume":"17","author":[{"given":"Ding\u2010Yun","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopedics, West China Hospital Sichuan University  Chengdu City Sichuan Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Na","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Evidence\u2010Based Medicine and Clinical Epidemiology, West China Hospital Sichuan University  Chengdu City Sichuan Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Evidence\u2010Based Medicine and Clinical Epidemiology, West China Hospital Sichuan University  Chengdu City Sichuan Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Qi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Evidence\u2010Based Medicine and Clinical Epidemiology, West China Hospital Sichuan University  Chengdu City Sichuan Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Evidence\u2010Based Medicine and Clinical Epidemiology, West China Hospital Sichuan University  Chengdu City Sichuan Province PR China"},{"name":"The Chinese Cochrane Center  Chengdu City Sichuan Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong\u2010Qi","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, West China Hospital Sichuan University  Chengdu City Sichuan Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18323"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13054"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.5.1435"},{"key":"e_1_2_8_7_1","volume-title":"Diabetes Atlas","author":"IDF (International Diabetes 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