{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:51:09Z","timestamp":1783705869359,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"PolarityTE","award":["Grant001"],"award-info":[{"award-number":["Grant001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic foot ulcers (DFUs) are a growing burden on patients and health care systems that often require multiple treatments of both conventional and advanced modalities to achieve complete wound closure. A novel autologous homologous skin construct (AHSC) has been developed to treat cutaneous defects with a single topical application, by leveraging the endogenous repair capabilities of the patient's healthy skin. The AHSC's ability to close DFUs with a single treatment was evaluated in an open\u2010label, single\u2010arm feasibility study. Eleven patients with DFUs extending up to tendon, bone, or capsule received a single topical application of AHSC. Closure was documented weekly with high\u2010resolution digital photography and wound planimetry. All 11 DFUs demonstrated successful graft take. Ten DFUs closed within 8\u2009weeks. The median time\u2010to\u2010complete closure was 25\u2009days. The mean percent area reduction for all 11 wounds at 4\u2009weeks was 83%. There were no adverse events related to the AHSC treatment site. This pilot study demonstrated AHSC may be a viable single application topical intervention for DFUs and warrants investigation in larger, controlled studies.<\/jats:p>","DOI":"10.1111\/iwj.13404","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T14:36:10Z","timestamp":1590503770000},"page":"1366-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Complete wound closure following a single topical application of a novel autologous homologous skin construct: first evaluation in an <scp>open\u2010label<\/scp>, <scp>single\u2010arm<\/scp> feasibility study in diabetic foot ulcers"],"prefix":"10.1111","volume":"17","author":[{"given":"David G.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Keck School of Medicine University of Southern California  California Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P.","family":"Orgill","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Galiano","sequence":"additional","affiliation":[{"name":"Northwestern University School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Glat","sequence":"additional","affiliation":[{"name":"Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions, Inc.  Cody Wyoming USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-7056","authenticated-orcid":false,"given":"Charles M.","family":"Zelen","sequence":"additional","affiliation":[{"name":"The Professional Education and Research Institute (PERI)  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Li","sequence":"additional","affiliation":[{"name":"The Angiogenesis Foundation  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1615439"},{"key":"e_1_2_7_3_1","volume-title":"Diabetic Foot: A Clinical Atlas","author":"Pendsey 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