{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:16:06Z","timestamp":1760202966454,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Arjo"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intermittent pneumatic compression of the lower limbs has been shown to have beneficial effects in patients with chronic ulceration. However, the intermittent compression cuff will normally be applied over the wound, which may produce discomfort or interfere with other treatments. Thigh\u2010only approaches to intermittent pneumatic compression could solve this problem. This study aimed to demonstrate if such a system would have positive effects on venous and arterial blood flow distal to the compression site, but proximal to wound sites. The distal venous and arterial effects of a prototype thigh\u2010only 3\u2010chamber sequential intermittent pneumatic compression system were tested in 20 healthy volunteers, and 13 patients with ulcers of various aetiologies using Doppler ultrasound. The system produced hyperaemic responses in the arterial flow of both test groups. The peak venous velocity on deflation of the first and second chambers of the cuff was also greater in the patients with ulceration than in the healthy volunteers (11.6 cm\/s vs 8.3 cm\/s, <jats:italic>P<\/jats:italic> = .1). This work demonstrates that compression of the thigh alone can produce positive haemodynamic effects in the calves of patients with chronic wounds, and that this approach should be investigated as a therapy to improve blood flow to wound sites.<\/jats:p>","DOI":"10.1111\/iwj.13418","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T05:26:44Z","timestamp":1592458004000},"page":"1483-1489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The use of intermittent pneumatic compression of the thigh to affect arterial and venous blood flow proximal to a chronic wound site"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7450-5923","authenticated-orcid":false,"given":"Rhys John","family":"Morris","sequence":"first","affiliation":[{"name":"Department of Medical Physics and Clinical Engineering University Hospital of Wales  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethan Sarah","family":"Ridgway","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Clinical Engineering University Hospital of Wales  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Patrick","family":"Woodcock","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Clinical Engineering University Hospital of Wales  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x02vm423oa"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X14552096"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"13","article-title":"Intermittent pneumatic compression therapy: a systematic review","volume":"45","author":"Feldman JL","year":"2012","journal-title":"Lymphology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2013.0033"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2018.01.019"},{"key":"e_1_2_7_7_1","article-title":"Intermittent pneumatic compression for treating venous leg ulcers","volume":"5","author":"Nelson EA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2017.22.Sup3.S41"},{"issue":"11","key":"e_1_2_7_9_1","first-page":"293","article-title":"Effect of high\u2010pressure, intermittent pneumatic compression for the treatment of peripheral arterial disease and critical limb ischemia in patients without a surgical option","volume":"27","author":"Alvarez OM","year":"2015","journal-title":"Wounds"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.08.059"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1348"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.11.1269"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12387"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2016.09.006"},{"key":"e_1_2_7_15_1","unstructured":"O'DohertyB. Optimisation of intermittent compression for the improvement of vascular inflow and outflow proximal to a wound site [PhD thesis]. Cardiff: Cardiff University;2008."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2004.00556.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.02.057"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.11.033"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/03091900601015147"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.13418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.13418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T03:31:36Z","timestamp":1744860696000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.13418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/iwj.13418"],"URL":"https:\/\/doi.org\/10.1111\/iwj.13418","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"type":"print","value":"1742-4801"},{"type":"electronic","value":"1742-481X"}],"subject":[],"published":{"date-parts":[[2020,6,17]]},"assertion":[{"value":"2020-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}