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Adipose tissue, containing adipose\u2010derived stem cells, and platelet rich plasma (PRP) are regenerative therapies rich in growth factors which may provide a solution to chronic wound healing. This study aimed to assess the feasibility of conducting a definitive randomised controlled trial (RCT) to investigate the efficacy of these therapies for the treatment of DFU. This was a single centre, feasibility, three\u2010arm, parallel group RCT. Eligible DFU patients were randomised on a 1:1:1 basis to three intervention arms: control (podiatry); fat grafting; fat grafting with PRP. The intervention was delivered once and patients were followed\u2010up for 12\u2009weeks. The primary objective was to assess measures of trial feasibility. Clinical outcomes and health\u2010related quality of life (HRQoL) were also evaluated. Three hundred and thirty four patients were screened and 32 patients (9.6%) were deemed eligible with 18 enrolled in the trial (6 per arm) over 17\u2009months. All participants completed the trial with no withdrawals or crossover. Participant engagement was high with most HRQoL questionnaires returned and only 4.8% follow\u2010up appointments missed. There were five adverse events (AEs) related to the trial with no serious AEs. Five (28%) of the wounds healed. There was no difference between any of the groups in terms of clinical outcomes. This feasibility study demonstrated that a multi\u2010centre RCT is safe and feasible with excellent patient engagement. We have highlighted crucial information regarding methodology and recruitment, which will guide future trial design. Registration number: NCT03085550 <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>. Registered 01\/03\/2017.<\/jats:p>","DOI":"10.1111\/iwj.13433","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T13:28:22Z","timestamp":1594128502000},"page":"1578-1594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Fat grafting and platelet\u2010rich plasma for the treatment of diabetic foot ulcers: A feasibility\u2010randomised controlled trial"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-7366","authenticated-orcid":false,"given":"Oliver J.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Royal Free Hospital  London UK"},{"name":"Division of Surgery and Interventional Science University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Leigh","sequence":"additional","affiliation":[{"name":"Department of Podiatry Royal Free Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5311-8833","authenticated-orcid":false,"given":"Muholan","family":"Kanapathy","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Royal Free Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Macneal","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery St George's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Jell","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Hachach\u2010Haram","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Royal Free Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics Royal Free Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ash","family":"Mosahebi","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Royal Free Hospital  London UK"},{"name":"Division of Surgery and Interventional Science University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Global report on diabetes 2016. 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