{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:05:17Z","timestamp":1783649117365,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic wounds in diabetics are difficult to treat, therefore, adjuvant therapies have been investigated. Bathing in CO<jats:sub>2<\/jats:sub>\u2010rich water (spa therapy) has been known in Europe for decades for its positive effect on peripheral vascular disorders. Recently, much effort has been invested in developing optimal application methods of CO<jats:sub>2<\/jats:sub>. Uses include subcutaneous injections of CO<jats:sub>2<\/jats:sub>, bathing in CO<jats:sub>2<\/jats:sub>\u2010enriched water, and transcutaneous application of CO<jats:sub>2<\/jats:sub>. To verify the effect of transcutaneous application of gaseous CO<jats:sub>2<\/jats:sub> on the healing of chronic diabetic wounds, a randomized double\u2010blind clinical research was designed. The research included 30 and 27 wounds in the study and control groups, respectively. In addition to standard treatment, patients in the study group received 20 therapies with medical\u2010grade CO<jats:sub>2<\/jats:sub> gas and the control group received the same treatment with air. Results showed significantly faster healing in the study group: 20 of the 30 wounds in the study group were healed compared with none in the control group. Mean wound surface and volume in the study group was reduced significantly (surface: 96%, <jats:italic>P<\/jats:italic> = .001, volume: 99%, <jats:italic>P<\/jats:italic> = .003) compared with a small reduction in the control group (surface: 25%, <jats:italic>P<\/jats:italic> = .383, volume: 27%, <jats:italic>P<\/jats:italic> = .178). Considering our results, transcutaneous application of gaseous CO<jats:sub>2<\/jats:sub> is an effective adjuvant therapy in diabetic chronic wound treatment.<\/jats:p>","DOI":"10.1111\/iwj.13436","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T12:30:32Z","timestamp":1594125032000},"page":"1607-1614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The effect of transcutaneous application of gaseous CO<sub>2<\/sub> on diabetic chronic wound healing\u2014A double\u2010blind randomized clinical trial"],"prefix":"10.1111","volume":"17","author":[{"given":"Milos","family":"Macura","sequence":"first","affiliation":[{"name":"Department for surgical infections University Medical center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-6671","authenticated-orcid":false,"given":"Helena","family":"Ban 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