{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:13:54Z","timestamp":1787948034684,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5U01DK119083"],"award-info":[{"award-number":["5U01DK119083"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK020572"],"award-info":[{"award-number":["P30DK020572"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetic foot ulcers commonly precede diabetic foot osteomyelitis (DFO) and once the latter occurs, surgical management is often performed. The presence of osteomyelitis is an independent risk factor for the development of re\u2010ulceration. We investigated the relationship between causative organisms in osteomyelitis and 1\u2010year diabetic foot outcomes (re\u2010ulceration, amputation, and death) following surgical management in an observational cohort of 223 patients. Univariate and multivariate analyses were performed for available demographic, clinical, and laboratory data. In addition, random forest plots were used to identify microbiologic predictors of 1\u2010year outcomes. Patients with osteomyelitis managed surgically were younger and exhibited more painful peripheral neuropathy than outpatients with diabetes alone (both\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.0001\n                    <jats:bold>)<\/jats:bold>\n                    . Osteomyelitis proximal margin cultures were diverse, at times polymicrobial, and included multidrug\u2010resistant organisms in 13.9% of the cohort. In patients who underwent surgery, 44.5% experienced a re\u2010ulceration on the same foot within 12\u2009months of surgery. The presence of multidrug\u2010resistant organisms on proximal bone culture was found to be a significant predictor of diabetic foot ulcer recurrence in univariate modelling (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001) and importance rankings. This is the first study to use prediction modelling to identify a relationship between multidrug\u2010resistant organisms and diabetic foot ulcer recurrence following DFO.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13439","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T08:58:15Z","timestamp":1594112295000},"page":"1634-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>Multidrug<\/scp>\n                    resistant organism predicts ulcer recurrence following surgical management of diabetic foot osteomyelitis"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2561-9243","authenticated-orcid":false,"given":"Brian M.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine Domino's Farms, Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ye","sequence":"additional","affiliation":[{"name":"Biostatistics Department School of Public Health, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis346"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01237.x"},{"key":"e_1_2_7_4_1","volume-title":"Epidemiology of diabetic foot infection in the metro\u2010detroit area with a focus on independent predictors for pathogens resistant to recommended empiric antimicrobial therapy. Open forum infectious diseases","author":"Henig O","year":"2018"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2003.00860.x"},{"key":"e_1_2_7_6_1","first-page":"288","article-title":"Infection of foot ulcers with Staphylococcus aureus associated with increased mortality in diabetic patients","volume":"3","author":"Mantey I","year":"2000","journal-title":"Commun Dis Public Health"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.02.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.01.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v7.30079"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2699"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1938640018770285"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2012.06.017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1380"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v8.i4.135"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humic.2017.09.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00551-07"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00696_1.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2013.04.025"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0146-2015"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/328796"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8070209"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.08.013"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3543"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.08.009"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0412-x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz092"},{"issue":"8","key":"e_1_2_7_29_1","first-page":"205","article-title":"The effect of withholding antibiotics prior to bone biopsy in patients with suspected osteomyelitis: a meta\u2010analysis of the literature","volume":"31","author":"Crisologo PA","year":"2019","journal-title":"Wounds Compend Clin Res Practice"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.13439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.13439","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:36:00Z","timestamp":1748338560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.13439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/iwj.13439"],"URL":"https:\/\/doi.org\/10.1111\/iwj.13439","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,7]]},"assertion":[{"value":"2020-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}