{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:29:09Z","timestamp":1792650549910,"version":"4.5.0"},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Fournier's Gangrene is a fulminating necrotizing fasciitis of the perineum and genitalia. Standard treatment involves immediate excision of all necrotic tissue, aggressive antibiotic coverage, and supportive medical care. Still, the infection is commonly fatal or disfiguring. Wound treatment with disinfected blowfly larvae (maggot debridement therapy or MDT) has been shown to be highly effective, with multiple studies demonstrating effective debridement, disinfection, and promotion of granulation tissue. MDT also has been associated with preservation of viable tissue and minimised blood loss. This report describes a prospective clinical study of MDT for Fournier's gangrene aimed to test the hypothesis that early use of maggots could decrease the number of surgical treatments required to treat Fournier's gangrene. Subjects were provided with one initial surgical excision, followed by debridement using only medical grade\n                    <jats:italic>Lucilia sericata<\/jats:italic>\n                    larvae. Only two subjects were enrolled, both diabetic men. Intensive care and culture\u2010directed antimicrobial coverage were administered as usual. Maggot debridement was associated with the disappearance of necrotic tissue, control of infection and granulation tissue growth. In both subjects, wounds healed without requiring further surgical resection or anatomical reconstruction. Maggot therapy decreased the number of surgical procedures that otherwise would have been necessary, and led to favourable outcomes.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13444","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T04:50:38Z","timestamp":1595307038000},"page":"1642-1649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical study of Maggot therapy for Fournier's gangrene"],"prefix":"10.1111","volume":"17","author":[{"given":"Alicia","family":"Fonseca\u2010Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Centro Interdisciplinario de Investigaci\u00f3n para el Desarrollo Integral Regional (CIIDIR) Instituto Polit\u00e9cnico Nacional (IPN), Unidad Oaxaca  Santa Cruz Xoxocotl\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo E.","family":"Sarmiento\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Surgery Clinica Hospital Bianni San Jose Oaxaca  Oaxaca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"P\u00e9rez\u2010Pacheco","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinario de Investigaci\u00f3n para el Desarrollo Integral Regional (CIIDIR) Instituto Polit\u00e9cnico Nacional (IPN), Unidad Oaxaca  Santa Cruz Xoxocotl\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Animal Biology Institute of Biology, University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Board Chair and Director BioTherapeutics, Education &amp; Research (BTER) Foundation  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"49","article-title":"Causes, presentation and survival of fifty\u2010seven patients with necrotizing fasciitis of the male genitalia","volume":"170","author":"Clayton MD","year":"1990","journal-title":"Sur Gynecol Obstet"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)46485-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(02)00058-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.05.021"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.09075.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.08.090"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01497.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-2-9136"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198105000-00003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)50351-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67236-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342407"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.1995.11719382"},{"key":"e_1_2_7_15_1","first-page":"A15","volume-title":"Diabetologia: Proceedings of the 36th Annual meeting of the European Association for the Study of Diabetes","author":"Markevich YO","year":"2000"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.10403.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2.446"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588407X205404"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2008.00564.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b773"},{"key":"e_1_2_7_21_1","first-page":"121","article-title":"Maggot debridement therapy in the treatment of complex diabetic wounds","volume":"70","author":"Marineau ML","year":"2011","journal-title":"Hawaii Med J"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12127"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.11.2030"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/592419"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00850.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102040-00003"},{"issue":"2","key":"e_1_2_7_27_1","first-page":"78","article-title":"Estudio comparativo de la eficacia de la larvaterapia (LT) para desbridar y controlar la carga bacteriana en \u00falceras venosas comparado con desbridamiento quir\u00fargico y aplicaci\u00f3n de un antimicrobiano t\u00f3pico. 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