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It is unknown whether this upfront financial investment represents good value for money. Thus the aim of this project is to evaluate the cost\u2010effectiveness of treating advanced DFU using continuous delivery of oxygen compared with negative pressure wound therapy from the perspective of the public health care payer in Ontario, Canada. A microsimulation model was constructed with inputs from peer\u2010reviewed journal publications and publicly available reports. The 5\u2010year costs and quality\u2010adjusted life\u2010years were compared between treatment and comparator. Sensitivity analyses were conducted to evaluate the robustness of results. The model predicted that continuous delivery of oxygen would cost $4800 less compared with negative pressure wound therapy and increased quality\u2010adjusted life years by 0.025. Lower cost and improved outcomes were observed in most scenario analyses. The results of this economic evaluation suggest that CDO therapy may reduce health care economic burden with a modest increase in quality of life outcomes. Health care decision\u2010makers should consider the inclusion of CDO for the treatment of DFU.<\/jats:p>","DOI":"10.1111\/iwj.13468","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T05:18:40Z","timestamp":1595913520000},"page":"1791-1808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["An economic evaluation examining the cost\u2010effectiveness of continuous diffusion of oxygen therapy for individuals with diabetic foot ulcers"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5037-0446","authenticated-orcid":false,"given":"Brian C.\u2010F.","family":"Chan","sequence":"first","affiliation":[{"name":"KITE \u2013 Toronto Rehabilitation Institute University Health Network  Toronto Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Campbell","sequence":"additional","affiliation":[{"name":"School of Physical Therapy, Faculty of Health Science Western University  London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"MargolisDJ MalayDS HoffstadOJ et al. 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