{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:07:42Z","timestamp":1791515262549,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, the emergence of antibiotic resistant pathogens made increasingly difficult to establish appropriate empiric antimicrobial therapy protocols for acute diabetic foot infection (DFI) treatment. Early recognition of the population at\u2010risk for multidrug\u2010resistant (MDR) bacterial infection is of paramount importance in order to decrease large\u2010spectrum antibiotic overuse. This study used retrospective cohort study in a multidisciplinary tertiary diabetic foot unit. Patients with severe DFI were included and divided according to their infection resistance profile (susceptible vs MDR bacteria). Data regarding their comorbidities and length of hospital stay were collected. The primary endpoint was to determine the risk factors for MDR infections and to evaluate if these were associated with an increased length of stay (LOS). A total of 112 microbial isolates were included. Predominance of Gram\u2010positive bacteria was observed and 22.3% of isolated bacteria were MDR. Previous hospitalisation was associated with a higher likelihood of MDR infection. MDR bacterial infection was also associated with an increased LOS (<jats:italic>P<\/jats:italic> =\u2009.0296). Our study showed a high incidence of MDR bacteria in patients with a DFI, especially in those who had a recent hospitalisation. MDR infections were associated with a prolonged LOS and represent a global public health issue for which emergent measures are needed.<\/jats:p>","DOI":"10.1111\/iwj.13473","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T12:02:14Z","timestamp":1598011334000},"page":"1835-1839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Multidrug\u2010resistant bacteria in diabetic foot infections: Experience from a portuguese tertiary centre"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7942-2107","authenticated-orcid":false,"given":"Tom\u00e1s","family":"Pessoa e Costa","sequence":"first","affiliation":[{"name":"Dermatology Department Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Duarte","sequence":"additional","affiliation":[{"name":"Dermatology Department Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lu\u00edsa","family":"Jo\u00e3o","sequence":"additional","affiliation":[{"name":"Dermatology Department Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Coelho","sequence":"additional","affiliation":[{"name":"Dermatology Department Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Formiga","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit, General Surgery Department Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Pinto","sequence":"additional","affiliation":[{"name":"Microbiology Department Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Neves","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit, General Surgery Department Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7547\/1030002"},{"issue":"9","key":"e_1_2_6_4_1","first-page":"CD009061","article-title":"Systemic antibiotics for treating diabetic foot infections","author":"Olid AS","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734619839815"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2699"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JRS-150689"},{"issue":"1","key":"e_1_2_6_9_1","first-page":"53","article-title":"Microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers in a Portuguese hospital","volume":"18","author":"Cabete J","year":"2011","journal-title":"Rev Port Cir Cardiotorac Vasc"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.10.001"},{"key":"e_1_2_6_11_1","first-page":"14","article-title":"Evaluation of the efficacy of a diabetic foot infection empirical antibiotic therapy protocol: a retrospective inpatient study","volume":"11","author":"Barbosa A","year":"2016","journal-title":"Revista Portuguesa de Diabetes"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.02.010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2010.10.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734614550311"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01237.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734614521236"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/jlp.jlp_106_18"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2008.02.005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2739"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.257.5073.1064"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.06.009"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3380"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.13473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:36:39Z","timestamp":1748352999000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.13473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,21]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/iwj.13473"],"URL":"https:\/\/doi.org\/10.1111\/iwj.13473","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,21]]},"assertion":[{"value":"2020-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}