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Surgical or endovascular treatments represent the first line of intervention; in addition, the adequate management of ulcers can guarantee not only a faster wound healing but also the improvement of the patient's prognosis. To speed up this process, negative pressure wound therapy (NPWT), platelet\u2010rich plasma (PRP), and other advanced moist wound dressing have been proposed. During Coronavirus disease 2019 (COVID\u201019) pandemic, many patients with CLI and diabetes mellitus had difficult access to advanced treatments with a significant reduction in life expectancy. We report the cases of patients with non\u2010healing ulcers and CLI treated with an empiric multistage approach after successful endovascular revascularisation; the postoperative course was eventful in all patients, and foot ulcers are currently in an advanced state of healing. The association between adequate revascularisation, systemic anti\u2010inflammatory, and antibiotic therapy with the multistage advanced medications ensures healing of ulcers, limb salvage, and improvement of patient prognosis.<\/jats:p>","DOI":"10.1111\/iwj.13476","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T12:00:58Z","timestamp":1598011258000},"page":"1863-1870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A multistage combined approach to promote diabetic wound healing in COVID\u201019 era"],"prefix":"10.1111","volume":"17","author":[{"given":"Raffaele","family":"Grande","sequence":"first","affiliation":[{"name":"Department of Surgery \u201cPietro Valdoni\u201d \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Fiori","sequence":"additional","affiliation":[{"name":"Department of 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