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With up to 3 million patients affected each year, hospital\u2010acquired pressure injuries (HAPIs) place a substantial burden on the US healthcare system. In the current study, US hospital discharge records from 9.6 million patients during the period from October 2009 through September 2014 were analysed to determine the incremental cost of hospital\u2010acquired pressure injuries by stage. Of the 46\u2009108 patients experiencing HAPI, 16.3% had Stage 1, 41.0% had Stage 2, 7.0% had Stage 3, 2.8% had Stage 4, 7.3% had unstageable, 14.6% had unspecified, and 10.9% had missing staging information. In propensity score\u2010adjusted models, increasing HAPI severity was significantly associated with higher total costs and increased overall length of stay when compared with patients not experiencing a HAPI at the index hospitalisation. The average incremental cost for a HAPI was $21\u2009767. Increasing HAPI severity was significantly associated with greater risk of in\u2010hospital mortality at the index hospitalisation compared with patients with no HAPI, as well as 1.5 to 2 times greater risk of 30\u2010, 60\u2010, and 90\u2010day readmissions. Additionally, increasing HAPI severity was significantly associated with increasing risk of other hospital\u2010acquired conditions, such as pneumonia, urinary tract infections, and venous thromboembolism during the index hospitalisation. By preventing pressure injuries, hospitals have the potential to reduce unreimbursed treatment expenditures, reduce length of stay, minimise readmissions, prevent associated complications, and improve overall outcomes for their patients.<\/jats:p>","DOI":"10.1111\/iwj.13482","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T09:50:59Z","timestamp":1598262659000},"page":"1924-1934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Risk of readmissions, mortality, and hospital\u2010acquired conditions across hospital\u2010acquired pressure injury (<scp>HAPI<\/scp>) stages in a <scp>US<\/scp> National Hospital Discharge database"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6504-910X","authenticated-orcid":false,"given":"Christina L.","family":"Wassel","sequence":"first","affiliation":[{"name":"Premier, Inc  Charlotte North Carolina 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