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Perfusion was measured with hyperspectral imaging and transcutaneous oxygen. We used paired <jats:italic>T<\/jats:italic> tests to compare continuous variables and independent T tests to compare healers and nonhealers. There was an increase from baseline to week 1 in TGF\u2010\u03b2 (<jats:italic>P<\/jats:italic> =\u2009.008), TNF\u2010\u03b1 (<jats:italic>P<\/jats:italic> =\u2009.014), VEGF (<jats:italic>P<\/jats:italic> =\u2009.008), PDGF (<jats:italic>P<\/jats:italic> =\u2009.087), and IGF\u20101 (<jats:italic>P<\/jats:italic> =\u2009.058); baseline to week 2 in TGF\u2010\u03b2 (<jats:italic>P<\/jats:italic> =\u2009.010), VEGF (<jats:italic>P<\/jats:italic> =\u2009.051), and IL\u20106 (<jats:italic>P<\/jats:italic> =\u2009.031); and baseline to week 3 with TGF\u2010\u03b2 (<jats:italic>P<\/jats:italic> =\u2009.055) and IL\u20106 (<jats:italic>P<\/jats:italic> =\u2009.054). There was a significant increase in transcutaneous oxygen after 1 week of treatment on both medial and lateral foot (<jats:italic>P<\/jats:italic> =\u2009.086 and .025). Fifty\u2010three percent of the patients had at least a 50% wound area reduction (healers). At baseline, there were no differences in cytokines between healers and nonhealers. However, there was an increase in CXCL8 after 1 week of treatment (<jats:italic>P<\/jats:italic> =\u2009.080) and IL\u20106 after 3\u2009weeks of treatment in nonhealers (<jats:italic>P<\/jats:italic> =\u2009.099). There were no differences in quantitative cultures in healers and nonhealers.<\/jats:p>","DOI":"10.1111\/iwj.13490","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T11:25:18Z","timestamp":1598354718000},"page":"1986-1995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effect of continuous diffusion of oxygen treatment on cytokines, perfusion, bacterial load, and healing in patients with diabetic foot ulcers"],"prefix":"10.1111","volume":"17","author":[{"given":"Lawrence A.","family":"Lavery","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Killeen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas 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