{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T06:33:28Z","timestamp":1792910008441,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic foot is challenging progressive disease which requires multisystemic control. Neuropathy, arteriopathy, and cellular responses should treated collaboratively. Despite all medical advances, diabetic foot can highly resulted with amputation and also re\u2010amputation can be required because of failed wound healing. In this study, we aimed to investigate the relation between blood parameters and amputation events. Diabetic 323 patients include to the study who referred to orthopaedic clinic for amputation. Amputation levels (amputation levels phalanx, metatarsal, lisfranc, syme, below knee, knee\u2010disarticulation, above\u2010knee amputation) and re\u2010amputations recorded and compared with routine blood parameters. Re\u2010amputation was observed at 69 patients. The significant difference detected between lower albumin, higher HbA1c, higher CRP levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in regards to gross amputation levels, and increased wound depth. Furthermore, lower albumin levels and higher levels of WBC, HbA1c, CRP, and Creatinine were detected in re\u2010amputation levels. Especially, HbA1c, CRP, and Creatinine levels were found as upper bound of reference line for re\u2010amputation. The statistically optimal HbA1c cutoff point for diabetes was \u22657.05%, with a sensitivity of 86% and a specificity of 59%. In according to our results, simple blood parameters can be useful for observing the progress of amputation in diabetic foot. Particularly, lower albumin, and higher HbA1c, CRP, and Creatinine levels detected as related with poor prognosis. Besides, screening of HbA1c level seems to be highly sensitive for detecting of re\u2010amputation possibility.<\/jats:p>","DOI":"10.1111\/iwj.13491","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T07:02:37Z","timestamp":1601967757000},"page":"1996-2004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Analysis of routine blood markers for predicting amputation\/re\u2010amputation risk in diabetic foot"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9012-8053","authenticated-orcid":false,"given":"An\u0131l","family":"G\u00fclc\u00fc","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology Alanya Alaaddin Keykubat University  Alanya 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