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As a result, a total of 23 RCTs (1445 patients) were included. Patients receiving dexmedetomidine combined with local anaesthetics had a lower rescue analgesia rate [risk ratio (RR): 0.48; 95% confidence interval (CI): 0.36\u20100.65] and lower rescue analgesic consumption [weighted mean difference (WMD): \u221210.80\u2009mg; 95%CI: \u221213.28 to \u22128.31\u2009mg] than patients receiving local anaesthetics alone. The dexmedetomidine\u2010related adverse reactions included bradycardia (RR: 1.33; 95%CI: 0.32\u20105.56) and hypotension (RR: 3.00; 95%CI: 0.49\u201018.42). In addition, the time to first analgesic request (WMD: 296.16\u2009minutes; 95%CI: 165.69\u2009minutes\u2009~\u2009426.63\u2009minutes), incidence of postoperative nausea and vomiting (PONV) and pain scores at 4 hours postoperatively were also significantly lower in patients receiving dexmedetomidine combined with local anaesthetics. This meta\u2010analysis demonstrated that the use of dexmedetomidine as an adjuvant to wound infiltration is effective for reducing the rescue analgesia rate, rescue analgesic consumption and PONV. In addition, limited evidence shows that dexmedetomidine can prolong postoperative analgesia for approximately 5 hours. Further investigations on dexmedetomidine\u2010related adverse reactions and the dose\u2013response effect of dexmedetomidine in wound infiltration are warranted.<\/jats:p>","DOI":"10.1111\/iwj.13517","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T06:18:30Z","timestamp":1604989110000},"page":"32-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["RETRACTED: Efficacy and safety of dexmedetomidine as an adjuvant to local wound infiltration anaesthesia: A meta\u2010analysis with trial sequential analysis of 23 randomised controlled trials"],"prefix":"10.1111","volume":"18","author":[{"given":"Yifeng","family":"Ren","sequence":"first","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu 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