{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:37:37Z","timestamp":1791265057526,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to summarise the clinical evidence supporting almost 40\u2009years of topical cadexomer iodine (CIOD) use in wound bed preparation by removing barriers to healing such as exudate, slough, bioburden, and infection and allowing chronic wound progression. A systematic review was conducted (Embase\/PubMed, November 2020) to identify relevant comparative studies meeting inclusion criteria. Meta\u2010analyses were performed using a fixed\u2010effects (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009&lt;\u200950%) or random\u2010effects model (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009\u2265\u200950%) depending on statistical heterogeneity. Dichotomous outcomes were reported as relative risk (RR) and continuous outcomes as mean difference (MD), with 95% confidence intervals. In total, 436 publications were identified of which 13 were comparative trials including outcomes of interest. Significant reductions in exudate, pus\/debris, slough, bioburden, and infection were reported in chronic wounds treated with CIOD, compared with standard of care (SOC). Meta\u2010analyses highlighted the positive impact of CIOD on mean wound area reduction (MD\u00a0=\u00a02.35\u2009cm<jats:sup>2<\/jats:sup>, 95% CI\u00a0=\u00a00.34\u20134.36, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0219) after eight weeks treatment and overall wound healing events compared to SOC; wounds including venous leg ulcers, diabetic foot ulcers, and pressure ulcers treated with CIOD were more than twice as likely to heal than those receiving SOC (RR\u00a0=\u00a02.30, 95% CI\u00a0=\u00a01.54\u20133.45, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). This meta\u2010analysis demonstrates the efficacy of CIOD on chronic wounds through removal of barriers to healing. CIOD should be considered in wound bed preparation and treatment protocols.<\/jats:p>","DOI":"10.1111\/iwj.13560","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T13:40:51Z","timestamp":1612964451000},"page":"586-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy of topical cadexomer iodine treatment in chronic wounds: Systematic review and meta\u2010analysis of comparative clinical trials"],"prefix":"10.1111","volume":"18","author":[{"given":"Kevin","family":"Woo","sequence":"first","affiliation":[{"name":"School of Nursing Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Dowsett","sequence":"additional","affiliation":[{"name":"East London NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Costa","sequence":"additional","affiliation":[{"name":"Smith &amp; Nephew Clinical and Medical Affairs  Kingston upon Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Ebohon","sequence":"additional","affiliation":[{"name":"Smith &amp; Nephew Clinical and Medical Affairs  Kingston upon Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-2240","authenticated-orcid":false,"given":"Emma J.","family":"Woodmansey","sequence":"additional","affiliation":[{"name":"Smith &amp; Nephew Clinical and Medical Affairs  Kingston upon Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Malone","sequence":"additional","affiliation":[{"name":"South West Sydney Limb Preservation and Wound Research  Sydney Australia"},{"name":"School of Medicine, Infectious Diseases and Microbiology Western Sydney University  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12142"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05321-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.8.4329"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03677.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.11.s2.1.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.3.154"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.1304S1.x"},{"key":"e_1_2_9_9_1","first-page":"60","article-title":"A combative healer with no ill\u2010effect. 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