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A scar\u2010prone constitute will accelerate HS formation and functional disorder, which deserves systemic therapy with oral medicine. To examine the oral therapeutic effectiveness on HS with convincing evidence of gross view and histological improvement, a rabbit ear HS model was employed with oral administration of asiaticoside (AS) at the doses of 12 and 24\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u2009d<jats:sup>\u22121<\/jats:sup> daily for 60 consecutive days. Gross observation and histological findings showed that oral AS treatment could significantly inhibit HS formation in a dose dependent manner. Semi\u2010quantification of scar elevation index at days 7, 15, 30, and 60, and quantitative polymerase chain reaction at days 30 and 60 also provided the evidences of reduced scar thickness and inhibited fibrotic gene expressions of <jats:italic>collagens I<\/jats:italic>, <jats:italic>III<\/jats:italic>, <jats:italic>TGF\u2010\u03b21<\/jats:italic>, <jats:italic>interleukins 1\u03b2<\/jats:italic>, <jats:italic>6<\/jats:italic> and <jats:italic>8<\/jats:italic>, and enhanced gene expression of <jats:italic>SMAD 7<\/jats:italic> and <jats:italic>PPAR\u2010\u03b3<\/jats:italic> with a dose\u2010dependent manner. These results indicated that AS is likely to serve as a systemic therapeutic agent of HS treatment for those who may have scar\u2010prone constitute via anti\u2010inflammation, inhibiting fibrotic process, and enhancing matrix degradation.<\/jats:p>","DOI":"10.1111\/iwj.13561","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T12:50:09Z","timestamp":1614948609000},"page":"598-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Inhibition of hypertrophic scar formation with oral asiaticoside treatment in a rabbit ear scar model"],"prefix":"10.1111","volume":"18","author":[{"given":"Jia","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Tissue Engineering Research  Shanghai 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