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Verapamil, a type of calcium channel blocker, is considered a candidate drug for the treatment of hypertrophic scars. Here, we report that the addition of verapamil to topical silicone gel enhances treatment outcomes of hypertrophic scars. Upon creation of hypertrophic scars with the rabbit ear model, varying concentrations of verapamil\u2010added silicone gel (0.1, 1, and 10\u00a0mg\/g) were applied daily for 28\u2009days. After the animals were euthanised, microscopic measurement was performed for (a) scar elevation index (SEI), (b) fibroblast count, and (c) capillary count. On gross analysis, features of hypertrophic scars were significantly alleviated in the verapamil\u2010added groups. On histologic examination, verapamil\u2010added groups showed (a) reduced SEI (1.93 (1.79\u20102.67) for control vs 1.34 (1.21\u20101.51) for silicone only and 1.13 (1.01\u20101.65) for verapamil\u2010added silicone), (b) fibroblast count 700.5 (599.5\u2010838.5) for control, 613.25 (461\u2010762.5) for silicone only, and 347.33 (182.5\u2010527) for verapamil\u2010added silicone), and (c) capillary formation (52 (35.5\u201096.5) for control, 46 (28\u201064.5) for silicone only, and 39.83(24\u201070) for verapamil\u2010added silicone) (Kruskal\u2010Wallis test, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). On western blot, expression levels of collagen I protein was lower in the 1\u00a0mg\/g and 10\u00a0mg\/g verapamil\u2010added silicone compared with control. Therefore, we suggest a therapeutic concentration of verapamil\u2010added silicone gel of at least over 1\u00a0mg\/g. Further study regarding maximally effective concentration and deeper insight into the mechanism of action should follow.<\/jats:p>","DOI":"10.1111\/iwj.13566","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:01:46Z","timestamp":1616025706000},"page":"647-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Verapamil\u2010containing silicone gel reduces scar hypertrophy"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-8414","authenticated-orcid":false,"given":"Jangyoun","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-940X","authenticated-orcid":false,"given":"Yu Na","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, College of Medicine The Catholic University of Korea  Seoul South Korea"},{"name":"Department of Biomedicine &amp; Health Sciences, College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Rha","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Eunpyeong St. Mary's Hospital The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwi Ju","family":"Kang","sequence":"additional","affiliation":[{"name":"Genewel Co., Ltd. Sagimakgol\u2010ro 62 beon\u2010gil Jungwon\u2010gu  Seongnam\u2010si Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Genewel Co., Ltd. Sagimakgol\u2010ro 62 beon\u2010gil Jungwon\u2010gu  Seongnam\u2010si Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"T&amp;R Biofab Executive Director\/Research Director, Regenerative Medicine Lab  Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-8059","authenticated-orcid":false,"given":"Jong Won","family":"Rhie","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, College of Medicine The Catholic University of Korea  Seoul South Korea"},{"name":"Department of Biomedicine &amp; Health Sciences, College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00224.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199709000-00021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003894"},{"issue":"4","key":"e_1_2_8_5_1","first-page":"781","article-title":"Topical silicone gel: a new treatment for hypertrophic scars","volume":"106","author":"Ahn 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