{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:53:07Z","timestamp":1787014387235,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Our purpose was to perform a meta\u2010analysis to evaluate the effect of Low\u2010level laser therapy (LLLT) on diabetic foot ulcers (DFUs). The PubMed, Cochrane, Embase, Web of Science, Chinese BioMedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), VIP and Wanfang databases were searched systematically up to August 27, 2020. Studies that met the inclusion criteria were included in the analysis. A total of 13 randomised controlled trials (RCTs) and 413 patients were analysed. Compared with the control group, LLLT significantly increased the complete healing rate (risk ratio [RR]\u00a0=\u00a02.10, 95% confidence interval [CI] 1.56\u20102.83,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.00001), reduced the ulcer area (standardised mean difference [SMD]\u00a0=\u00a03.52, 95% CI 1.65\u20105.38,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.0002), and shortened the mean healing time (SMD\u00a0=\u00a0\u22121.40, 95% CI \u22121.90 to \u22120.91,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.00001) of patients with DFUs. The quality of the evidence was very low according to the GRADE system. LLLT is a promising and effective adjuvant treatment to accelerate the healing of DFUs. Further evidence from larger samples and higher quality RCTs is needed to prove the effect of LLLT and to determine the most appropriate parameters for the healing of DFUs.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13577","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T20:30:15Z","timestamp":1615321815000},"page":"763-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The effect of low\u2010level laser therapy on diabetic foot ulcers: A meta\u2010analysis of randomised controlled trials"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-1767","authenticated-orcid":false,"given":"Jing","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangqiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyuan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1928-2178","authenticated-orcid":false,"given":"Zhiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1598"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2245"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci17-0029"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13054"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12404"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1067-2516(07)60001-5"},{"issue":"12","key":"e_1_2_10_9_1","first-page":"2683","article-title":"Acceleration of diabetic wound healing by a cryopreserved living dermal substitute created by micronized amnion seeded with fibroblasts","volume":"7","author":"Zheng YJ","year":"2015","journal-title":"Am J Transl Res"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0141076816688346"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67700-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2009.2680"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2018.4455"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13470"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.08.014"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13067"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1352.040"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/626127"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-198905000-00015"},{"issue":"5","key":"e_1_2_10_21_1","first-page":"138","article-title":"Physical therapy in the treatment of venous leg ulcers: biophysical mechanisms","volume":"24","author":"Taradaj J","year":"2012","journal-title":"Wounds"},{"issue":"5","key":"e_1_2_10_22_1","first-page":"621","article-title":"The effect of laser beams on the growth of hair in mice","volume":"9","author":"Mester E","year":"1968","journal-title":"Radiobiol Radiother (Berl)"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(71)90482-X"},{"issue":"1","key":"e_1_2_10_24_1","first-page":"49","article-title":"Laser stimulation of wound healing","volume":"17","author":"Mester E","year":"1976","journal-title":"Acta Chir Acad Sci Hung"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-1880-4"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2007.2098"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2013.3586"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2007.02.005"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-2109-2"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734620914439"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.07.014"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12399"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-9-199711010-00008"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"issue":"7109","key":"e_1_2_10_38_1","first-page":"629","article-title":"Bias in meta\u2010analysis detected by a simple, graphical test","volume":"315","author":"Egger M","year":"1997","journal-title":"BMJ Open Diabetes Res Care"},{"issue":"3","key":"e_1_2_10_39_1","first-page":"107","article-title":"Effects of low level laser therapy and high voltage stimulation on diabetic wound healing","volume":"46","author":"Ort\u00edz MCS","year":"2014","journal-title":"Rev Univ Ind Santander Salud"},{"issue":"103","key":"e_1_2_10_40_1","first-page":"20","article-title":"Effect of Ga\u2010as laser on decrease of wound surface area and ABI value in diabetic foot ulcers","volume":"25","author":"Hoseini Sanati M","year":"2016","journal-title":"J Zanjan Univ Med Sci Health Serv"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20789"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-011-0393-4"},{"issue":"2","key":"e_1_2_10_43_1","first-page":"104","article-title":"Application of semiconductor laser to accelerate the healing of diabetic foot ulcers","volume":"25","author":"Chen HJ","year":"2003","journal-title":"Chin J Phys Med Rehab"},{"issue":"8","key":"e_1_2_10_44_1","first-page":"20","article-title":"The efficiency of laser on the treatment of diabetic foot ulcer","volume":"13","author":"Chi LX","year":"2002","journal-title":"Hainan Med J"},{"issue":"13","key":"e_1_2_10_45_1","first-page":"126","article-title":"Low\u2010intensity he\u2010ne laser irradiation assisted treatment of diabetic foot comprehensive nursing experience","volume":"15","author":"Cui ZH","year":"2009","journal-title":"IMHGN"},{"issue":"16","key":"e_1_2_10_46_1","first-page":"1388","article-title":"Diabetic foot ulcer treated with 650 nm semiconductor laser after surgical treatment:a clinical study","volume":"25","author":"Ouyang ZS","year":"2010","journal-title":"Clin Focus"},{"issue":"11","key":"e_1_2_10_47_1","first-page":"92","article-title":"Observation on the effect of he\u2010ne laser irradiation combined with surgical debridement in the treatment of 24 cases of diabetic foot ulcer","volume":"14","author":"Zhang LJ","year":"2012","journal-title":"Chin Commun Doctors"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2858"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000225430.42531.c2"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2004.12.024"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2012.0125"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900090513"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12583090"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-007-0491-5"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1283"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021873"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10123"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSTQE.2016.2561201"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-865020150120000010"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0080-623420160000500013"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.01.228"},{"issue":"5","key":"e_1_2_10_63_1","first-page":"8","article-title":"Review of literature on low\u2010level laser therapy benefits for nonpharmacological pain control in chronic pain and osteoarthritis","volume":"24","author":"Dima R","year":"2018","journal-title":"Altern Ther Health Med"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22559"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2005.23.289"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.13577","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T23:24:34Z","timestamp":1744845874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.13577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,9]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/iwj.13577"],"URL":"https:\/\/doi.org\/10.1111\/iwj.13577","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,9]]},"assertion":[{"value":"2021-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}