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This integrative review presents the current evidence to establish the role of modified compression therapy (MCT) in treatment of mixed arterial venous leg ulcers (MAVLU). A literature search was conducted using the electronic databases CINAHL, MEDLINE, PUBMED, and Embase. Ten studies met the eligibility criteria and were subsequently analysed. Our review concludes that MCT, with compression pressures between 20 and 30\u2009mmHg, can promote healing in MAVLU with moderate arterial insufficiency (0.5\u00a0\u2264\u2009ABPI \u22640.8). If ABPI is &lt;0.5, MCT can be considered once restoration of acceptable ABPI is achieved. Intolerance, lack of response or further deterioration of disease within 3\u00a0months should prompt further arterial imaging and intervention. MCT is generally well tolerated with no adverse outcomes reported. A holistic yet individualised approach is vital in order to account for all factors influencing this patient\u2010led decision\u2010making process, ultimately ensuring effective treatment, which improves patient's quality of life and reduces socioeconomic burden of the disease.<\/jats:p>","DOI":"10.1111\/iwj.13585","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T02:40:07Z","timestamp":1616121607000},"page":"822-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Modified compression therapy in mixed arterial\u2013venous leg ulcers: An integrative review"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1665-3204","authenticated-orcid":false,"given":"Sheryl Li Xin","family":"Lim","sequence":"first","affiliation":[{"name":"Blackpool Victoria Hospital Blackpool Teaching Hospitals  Blackpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui En","family":"Chung","sequence":"additional","affiliation":[{"name":"Royal Stoke University Hospital University Hospital North Midlands  Stoke\u2010on\u2010Trent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Holloway","sequence":"additional","affiliation":[{"name":"Cardiff University School of Medicine  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith G.","family":"Harding","sequence":"additional","affiliation":[{"name":"FRCS Wound Healing Research Unit Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"issue":"15","key":"e_1_2_9_2_1","first-page":"2607","article-title":"Venous leg ulcers","volume":"2016","author":"Nelson EA","year":"2016","journal-title":"BMJ Clin Evid"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.115606"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2006.05.001"},{"issue":"1368","key":"e_1_2_9_5_1","first-page":"1","article-title":"Assessment and management of leg ulcers in the community and an outpatient clinic","volume":"126","author":"Benoiton LA","year":"2013","journal-title":"N Z Med J"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009283"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12603"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2008.17.Sup6.30706"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2012.21.4.168"},{"key":"e_1_2_9_10_1","unstructured":"SIGN.Management of chronic venous leg ulcers.2010;"},{"key":"e_1_2_9_11_1","unstructured":"National Institute for Health and Care Excellence Clinical Knowledge Summaries [NICE CKS].Leg ulcer\u2014venous. 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