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Of 7077 patients with chronic leg oedema, 12.70% had wounds. Independent risk factors were: peripheral arterial disease (odds ratio (OR) 4.87, 95% confidence intervals (CI) 3.63\u20106.52), cellulitis within the past 12\u2009months (OR 2.69, 95% CI 2.25\u20103.21), secondary lymphoedema (OR 2.64, 95% CI 1.93\u20103.60), being male (OR 2.08, 95% CI 1.78\u20102.44), being over 85\u2009years of age (OR 1.80, 95% CI 1.23\u20102.62), underweight (OR 1.79, 95% CI 1.14\u20102.79), bed bound (OR\u00a01.79, 95% CI 1.01\u20103.16), chair bound (OR 1.52, 95% CI 1.18\u20101.97), diabetes (OR 1.47, 95% CI 1.23\u20101.77), and walking with aid (OR 1\u00b741, 95% CI 1.17\u20101.69). 43.22% of those with wounds had clinically defined well\u2010controlled oedema, associated with a significantly lower risk of wounds (OR 0.50, 95% CI 0.42\u20100.58, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Hard\/fibrotic tissue (OR 1.71, 95% CI 1.19\u20102.48), and a positive Stemmers sign (OR 1.57, 95% CI 1.05\u20102.35) were associated with wounds. The study reinforces the importance of measures to control oedema, as controlled swelling was associated with a 50% lower risk of wounds.<\/jats:p>","DOI":"10.1111\/iwj.13642","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T04:35:32Z","timestamp":1626237332000},"page":"411-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Wounds in chronic leg oedema"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-2694","authenticated-orcid":false,"given":"Ewa Anna","family":"Burian","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Venereology, Wound Healing Centre Bispebjerg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonny","family":"Karlsmark","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology, Wound Healing Centre Bispebjerg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"N\u00f8rregaard","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology, Wound Healing Centre Bispebjerg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kirketerp\u2010M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology, Wound Healing Centre Bispebjerg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Scott","family":"Kirsner","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9782-0181","authenticated-orcid":false,"given":"Peter John","family":"Franks","sequence":"additional","affiliation":[{"name":"Centre for Research and Implementation of Clinical Practice  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Qu\u00e9r\u00e9","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine Montpellier University Hospital Centre, University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Joy","family":"Moffatt","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology, Wound Healing Centre Bispebjerg Hospital  Copenhagen Denmark"},{"name":"Centre for Research and Implementation of Clinical Practice  London UK"},{"name":"Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Hippocrates.The Genuine Works of Hippocrates: Volume 2. 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