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The suction blister method leads to the artificial and controlled separation of dermis and epidermis. Therefore, time to blister formation may be used as outcome measuring the strength of dermo\u2010epidermal adhesion. We conducted an exploratory, randomised, controlled trial with a split\u2010body design on forearms in healthy female subjects (n\u00a0=\u00a012; mean age 70.3 [SD 2.1] years). Forearms assigned to the intervention were treated twice daily with petrolatum for 8\u2009weeks. Suction blisters were induced on forearms after 4 and 8\u2009weeks and time to blister formation was measured. Stratum corneum and epidermal hydration were measured and epidermal thickness was assessed via optical coherence tomography. Time to blistering was longer and stratum corneum as well as epidermal hydration was consistently higher in intervention skin areas. We conclude that topical application of basic skin care products may improve mechanical adhesion of the dermo\u2010epidermal junction and that the parameter \u201ctime to blistering\u201d is a suitable outcome to measure dermo\u2010epidermal adhesion strength in clinical research.<\/jats:p>","DOI":"10.1111\/iwj.13643","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T06:41:00Z","timestamp":1623652860000},"page":"426-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effect of a basic skin care product on the structural strength of the dermo\u2010epidermal junction: An exploratory, randomised, controlled split\u2010body trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5947-847X","authenticated-orcid":false,"given":"Monira","family":"El Genedy\u2010Kalyoncu","sequence":"first","affiliation":[{"name":"Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6024-6841","authenticated-orcid":false,"given":"Claudia","family":"Richter","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5027-4112","authenticated-orcid":false,"given":"Christian","family":"Surber","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-3752","authenticated-orcid":false,"given":"Ulrike","family":"Blume\u2010Peytavi","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0750-3818","authenticated-orcid":false,"given":"Jan","family":"Kottner","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Charit\u00e9 Center for Health and Human Sciences Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization (WHO). 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