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A model\u2010based cost\u2010effectiveness analysis was conducted from the German statutory health insurance perspective, following German specific and international recommendations of good research practice. An individual\u2010level (microsimulation) state\u2010transition model has been used with a cycle length of 1\u2009week and time horizon of 6\u2009months. Several comprehensive systematic reviews were conducted to inform all model inputs, including clinical parameters, efficacy, quality of life, resources utilisation, and cost inputs. In addition, primary data from two clinical trials were used. Based on this cost\u2010effectiveness analysis, using superabsorbent wound dressings instead of the SoC dressings of patients with moderate\u2010to\u2010highly exuding leg ulcers in Germany can lead to an improved healing rate of 2.57% (benefit ratio 1.08), improved health\u2010related quality of life of 0.152 quality\u2010adjusted life weeks, and total direct cost savings of \u20ac771 per patient in 6\u2009months. Robustness of results was confirmed in sensitivity and scenario analyses.<\/jats:p>","DOI":"10.1111\/iwj.13645","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T07:00:33Z","timestamp":1627974033000},"page":"447-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cost\u2010effectiveness analysis of superabsorbent wound dressings in patients with moderate\u2010to\u2010highly exuding leg ulcers in Germany"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7146-1267","authenticated-orcid":false,"given":"Vladica M.","family":"Veli\u010dkovi\u0107","sequence":"first","affiliation":[{"name":"Health Economics and Outcome Research (HEOR) Department HARTMANN GROUP  Heidenheim Germany"},{"name":"Institute of Public Health, Medical Decision Making and Health Technology Assessment UMIT  Hall Tirol Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mate","family":"Szilcz","sequence":"additional","affiliation":[{"name":"Medical Epidemiology and Biostatistics Department Karolinska Institute  Stockholm Stockholm County Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Milo\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Biostatistics Department University of Ni\u0161  Ni\u0161 Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Godfrey","sequence":"additional","affiliation":[{"name":"Health Economics and Outcome Research (HEOR) Department HARTMANN GROUP  Heidenheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Siebert","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Medical Decision Making and Health Technology Assessment UMIT  Hall Tirol Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.10.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01089.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348331"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2010.00660.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009283"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.Sup4.S4"},{"key":"e_1_2_10_9_1","unstructured":"HardingK CarvilleK ChadwickP MooreZ Nicod\u00e8meM PercivalS RomanelliM SchultzG TariqG.WUWHS Consensus Document: Wound Exudate effective assessment and management.2019."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CWCMR.S60315"},{"key":"e_1_2_10_11_1","unstructured":"Vincenzo AtellaJC G\u00e9rarddePouvourville DavidHenry MauriceMcGregor AlistairMcGuire ErikNord UweSiebert.Methods for Assessment of the Relation of Benefits to Costs in the German Statutory Health Care System.2008https:\/\/www.iqwig.de\/download\/General_Methods_for_the_Assessment_of_the_Relation_of_Benefits_to_Costs.pdf"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X12455463"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj.f1049","article-title":"Consolidated health economic evaluation reporting standards (CHEERS) statement","volume":"346","author":"Husereau D","year":"2013","journal-title":"BMJ: British Med J"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-017-0509-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2020.29.3.174"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2020.29.6.340"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.1629"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2018.1497976"},{"key":"e_1_2_10_19_1","unstructured":"CaroJJea.Methods for Assessment of the Relation of Benefits to Costs in the German Statutory Health Care System.2008https:\/\/www.iqwig.de\/download\/General_Methods_for_the_Assessment_of_the_Relation_of_Benefits_to_Costs.pdf"},{"key":"e_1_2_10_20_1","unstructured":"Sozialgesetzbuch (SGB) F\u00fcnftes Buch (V) \u2010 Gesetzliche Krankenversicherung \u2010 (Artikel 1 des Gesetzes v. 20. 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