{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:44Z","timestamp":1787014364225,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is an urgent need for interventions that improve healing time, prevent amputations and recurrent ulceration in patients with diabetes\u2010related foot wounds. In this randomised, open\u2010label trial, participants were randomised to receive an application of non\u2010cultured autologous skin cells (\u201cspray\u2010on\u201d skin; ReCell) or standard care interventions for large (&gt;6\u00a0cm\n                    <jats:sup>2<\/jats:sup>\n                    ), adequately vascularised wounds. The primary outcome was complete healing at 6\u00a0months, determined by assessors blinded to the intervention. Forty\u2010nine eligible foot wounds in 45 participants were randomised. An evaluable primary outcome was available for all wounds. The median (interquartile range) wound area at baseline was 11.4 (8.8\u201017.6) cm\n                    <jats:sup>2<\/jats:sup>\n                    . A total of 32 (65.3%) index wounds were completely healed at 6\u00a0months, including 16 of 24 (66.7%) in the spray\u2010on skin group and 16 of 25 (64.0%) in the standard care group (unadjusted OR [95% CI]: 1.13 (0.35\u20103.65),\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.845). Lower body mass index (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.002) and non\u2010plantar wounds (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.009) were the only patient\u2010 or wound\u2010related factors associated with complete healing at 6\u00a0months. Spray\u2010on skin resulted in high rates of complete healing at 6\u00a0months in patients with large diabetes\u2010related foot wounds, but was not significantly better than standard care (Australian New Zealand Clinical Trials Registry: ACTRN12618000511235).\n                  <\/jats:p>","DOI":"10.1111\/iwj.13646","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T10:35:33Z","timestamp":1624358133000},"page":"470-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Wound healing with \u201cspray\u2010on\u201d autologous skin grafting (\n                    <scp>ReCell<\/scp>\n                    ) compared with standard care in patients with large diabetes\u2010related foot wounds: an open\u2010label randomised controlled trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Laurens","family":"Manning","sequence":"first","affiliation":[{"name":"Harry Perkins Research Institute, Fiona Stanley Hospital, Medical School University of Western Australia Murdoch Western Australia Australia"},{"name":"Multidisciplinary Diabetes Foot Ulcer Service Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Infectious Diseases Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-3960","authenticated-orcid":false,"given":"Ivana Bastos","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Multidisciplinary Diabetes Foot Ulcer Service Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Podiatry Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gittings","sequence":"additional","affiliation":[{"name":"Department of Burns Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hiew","sequence":"additional","affiliation":[{"name":"Multidisciplinary Diabetes Foot Ulcer Service Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Podiatry Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Ryan","sequence":"additional","affiliation":[{"name":"Multidisciplinary Diabetes Foot Ulcer Service Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Podiatry Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mendel","family":"Baba","sequence":"additional","affiliation":[{"name":"Multidisciplinary Diabetes Foot Ulcer Service Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Podiatry Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Raby","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Burns Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keryln","family":"Carville","sequence":"additional","affiliation":[{"name":"Silver Chain Group and Curtin University Wilson Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Norman","sequence":"additional","affiliation":[{"name":"Harry Perkins Research Institute, Fiona Stanley Hospital, Medical School University of Western Australia Murdoch Western Australia Australia"},{"name":"Multidisciplinary Diabetes Foot Ulcer Service Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Vascular Surgery Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy Angela","family":"Davis","sequence":"additional","affiliation":[{"name":"Medical School, Fremantle Hospital University of Western Australia Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Burns Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Jane","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Harry Perkins Research Institute, Fiona Stanley Hospital, Medical School University of Western Australia Murdoch Western Australia Australia"},{"name":"Multidisciplinary Diabetes Foot Ulcer Service Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Endocrinology Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Carsten","family":"Ritter","sequence":"additional","affiliation":[{"name":"Multidisciplinary Diabetes Foot Ulcer Service Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Medical School, Fremantle Hospital University of Western Australia Fremantle Western Australia Australia"},{"name":"Medical School Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"e3266","DOI":"10.1002\/dmrr.3266","article-title":"Practical guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update)","volume":"36","author":"Schaper NC","year":"2020","journal-title":"Diabetes Metab Res 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a new technique for skin regeneration in diabetic and vascular ulcers","volume":"22","author":"Chant H","year":"2013","journal-title":"J Wound Care"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12844"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-019-0362-x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S154304"},{"issue":"1","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"e3268","DOI":"10.1002\/dmrr.3268","article-title":"Definitions and criteria for diabetic foot disease","volume":"36","author":"Van Netten JJ","year":"2020","journal-title":"Diabetes Metab Res 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