{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:02:34Z","timestamp":1794002554434,"version":"4.8.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The preparation of hydrogels for wound healing properties with high antibacterial activities and good biosafety concurrently can be relatively challenging. For addressing these issues, we report on the synthesis and characterisation of a nanocomposite hydrogel dressing by introducing the silver nanoparticles in hydroxypropyl methylcellulose\u2010hydroxyapatite scaffold hydrogel (HMC\u2010HA\/AgNPs). The different concentrations of AgNPs in HMC\u2010HA\/AgNPs hydrogels were confirmed by swelling ratio, degradation, and gelatin time. The synthesised HMC\u2010HA\/AgNPs hydrogels were further characterised using the UV\u2010visible, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectrum, and X\u2010ray diffraction. The results showed that the novel HMC\u2010HA\/AgNPs hydrogel exhibited a porous 3D network and high mechanical properties because of the inter\u2010molecular and intra\u2010molecular interactions. The AgNPs give the HMC\u2010HA hydrogels excellent antibacterial activities against both\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , without any chemical reductant and cross\u2010linking agent required endows the hydrogel high biocompatibility. More importantly, HMC\u2010HA\/AgNPs effectively repaired wound defects in mice models, and wound healing reached 94.5\u2009\u00b1\u20091.4% within 16\u2009days. The HMC\u2010HA hydrogel with AgNPs showed excellent antimicrobial activity and burn wound healing. Therefore, these HMC\u2010HA\/AgNPs hydrogels have great potential as an injectable hydrogel for wound healing activity in children with burn injuries.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13664","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T07:46:37Z","timestamp":1630568797000},"page":"666-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["An injectable metal nanoparticle containing cellulose derivative\u2010based hydrogels: Evaluation of antibacterial and in vitro\u2010vivo wound healing activity in children with burn injuries"],"prefix":"10.1111","volume":"19","author":[{"given":"Yuming","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Yantai Yantaishan Hospital  Yantai 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