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The great heterogeneity of wounds makes it difficult to match groups, and this is only possible with multivariate stratification and\/or very large numbers of subjects. The substantial time taken for wounds to heal necessitates a very lengthy study. Consequently, high quality randomised controlled trials demonstrating an effect of an intervention to a satisfactory level of statistical significance and with a satisfactory level of generalisability are extremely rare. This study determines that the healing of venous leg ulcers receiving multi\u2010component compression bandaging follows a linear trajectory over a 4\u2010week period, as measured by gross area healed, percentage area healed, and advance of the wound margin. The linear trajectories of these surrogates make it possible to identify an acceleration in healing resulting from an intervention, and allows self\u2010controlled or crossover designs with attendant advantages of statistical power and speed. Of the metrics investigated, wound margin advance was the most linear, and was also independent of initial ulcer size.<\/jats:p>","DOI":"10.1111\/iwj.13669","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T06:43:21Z","timestamp":1628577801000},"page":"734-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Measuring progress to healing: A challenge and an opportunity"],"prefix":"10.1111","volume":"19","author":[{"given":"Richard Hillson","family":"Bull","sequence":"first","affiliation":[{"name":"Accelerate CIC, Centenary Wing, St Joseph's Hospice  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Louise","family":"Staines","sequence":"additional","affiliation":[{"name":"Education and Research\/Clinical Lead Wound Care, Accelerate CIC, Centenary Wing, St Joseph's Hospice  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes Juguilon","family":"Collarte","sequence":"additional","affiliation":[{"name":"North West Division (Central London, Hammersmith &amp; Fulham and West London), St Charles Centre for Health &amp; Wellbeing  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan Shirreffs","family":"Bain","sequence":"additional","affiliation":[{"name":"Duncan Bain Consulting  Kings Langley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola M.","family":"Ivins","sequence":"additional","affiliation":[{"name":"Welsh Wound Innovation Centre  Pontyclun UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith Gordon","family":"Harding","sequence":"additional","affiliation":[{"name":"Wound Healing Research WWII Ltd (Welsh Wound Innovation Initiative), Welsh Wound Innovation Centre  Pontyclun UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70295-D"},{"key":"e_1_2_8_3_1","first-page":"213","article-title":"A mathematical model for the analysis of experimental wound healing data","volume":"3","author":"Hokanson JA","year":"1991","journal-title":"Wounds"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"33S","article-title":"Care of venous ulcers","volume":"45","author":"Falanga V","year":"1999","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.7.773"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890460053006"},{"key":"e_1_2_8_7_1","first-page":"150","article-title":"Utilizing survival analysis techniques in chronic wound healing studies","volume":"6","author":"Polansky M","year":"1994","journal-title":"Wounds"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681300700508"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03478.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2003.12.5.26493"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(96)80021-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2016.07.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(84)90213-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-9659(04)90128-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00328.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.7547\/15-004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.7548"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000394028.64777.f7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2009.18.4.41608"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-3-28"},{"issue":"11","key":"e_1_2_8_22_1","article-title":"Compression for venous leg ulcers","volume":"11","author":"O'Meara S","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198401053100106"},{"key":"e_1_2_8_24_1","unstructured":"AdvaMed Wound Healing and Tissue Regeneration Sector. 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