{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:18:46Z","timestamp":1790954326217,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The retrospective pragmatic real\u2010world data (RWD) study compared the healing outcomes of diabetic foot ulcers (DFUs) treated with either ovine forestomach matrix (OFM) (n\u00a0=\u00a01150) or collagen\/oxidised regenerated cellulose (ORC) (n\u00a0=\u00a01072) in out\u2010patient wound care centres. Median time to wound closure was significantly (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u2009.0015) faster in the OFM group (14.6\u00a0\u00b1\u20090.5\u2009weeks) relative to the collagen\/ORC group (16.4\u00a0\u00b1\u20090.7). A sub\u2010group analysis was performed to understand the relative efficacy in DFUs requiring longer periods of treatment and showed that DFUs treated with OFM healed up to 5.3\u2009weeks faster in these challenging wounds. The percentage of wounds closed at 36\u2009weeks was significantly improved in OFM treated DFUs relative to the collagen\/ORC. A Cox proportional hazards analysis showed OFM\u2010treated wounds had a 18% greater probability of healing versus wounds managed with collagen\/ORC, and the probability increased to 21% when the analysis was adjusted for multiple variables. This study represents the first large retrospective RWD analysis comparing OFM and collagen\/ORC and supports the clinical efficacy of OFM in the treatment of DFUs.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13670","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T02:57:53Z","timestamp":1628305073000},"page":"741-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Retrospective real\u2010world comparative effectiveness of ovine forestomach matrix and collagen\/\n                    <scp>ORC<\/scp>\n                    in the treatment of diabetic foot ulcers"],"prefix":"10.1111","volume":"19","author":[{"given":"Brandon A.","family":"Bosque","sequence":"first","affiliation":[{"name":"Aroa Biosurgery Limited  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Frampton","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine (Christchurch) Otago University  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail E.","family":"Chaffin","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery Tulane University School of Medicine  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Bohn","sequence":"additional","affiliation":[{"name":"Department of Surgery Central Michigan University  Tawas City Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Woo","sequence":"additional","affiliation":[{"name":"Queen's School of Nursing Queen's University  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"DeLeonardis","sequence":"additional","affiliation":[{"name":"DSA Health  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Lepow","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery and Endovascular Therapy Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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