{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:18:48Z","timestamp":1790954328092,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetic foot ulcers (DFUs) are at risk for detrimental complications even with current, standard of care (SOC) treatments. The primary objective of this randomised controlled trial was to compare a unique resorbable glass microfiber matrix (Mirragen; Advanced Wound Matrix [BBGFM]; ETS Wound Care, Rolla, Missouri) compared with a standard of care group (SOC, collagen alginate dressing) at 12\u2009weeks. Both groups received standard diabetic foot care including glucose monitoring, weekly debridements when needed and an offloading device. The primary endpoint was proportion of full\u2010thickness, non\u2010infected, non\u2010ischaemic wounds healed at 12\u2009weeks, with secondary endpoints including percent area reduction (PAR) and changes in Semmes\u2010Weinstein monofilament testing. The result illustrated in the intent\u2010to\u2010treat analysis at 12\u2009weeks showed that 70% (14\/20) of the BBGFM\u2010treated DFUs healed compared with 25% (5\/20) treated with SOC alone (adjusted\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.006). Mean PAR at 12\u2009weeks was 79% in the BBGFM group compared with 37% in the SOC group (adjusted\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.027). Mean change in neuropathic score between baseline and up to 12\u2009weeks of treatment was 2.0 in the BBGFM group compared with \u22120.6 in the SOC group where positive improvement in scores are better (adjusted\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.008). The mean number of BBGFM applications was 6.0. In conclusion, adding BBGFM to SOC significantly improved wound healing with no adverse events related to treatment compared with SOC alone.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13675","type":"journal-article","created":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T15:38:26Z","timestamp":1629560306000},"page":"791-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["A multi\u2010centre, single\u2010blinded randomised controlled clinical trial evaluating the effect of resorbable glass fibre matrix in the treatment of diabetic foot ulcers"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-9175","authenticated-orcid":false,"given":"David G.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Department of Surgery Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-7310","authenticated-orcid":false,"given":"Dennis P.","family":"Orgill","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-6483","authenticated-orcid":false,"given":"Robert D.","family":"Galiano","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-8603","authenticated-orcid":false,"given":"Paul M.","family":"Glat","sequence":"additional","affiliation":[{"name":"Department of Surgery Drexel University School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"DiDomenico","sequence":"additional","affiliation":[{"name":"Lower Extremity Institute for Research and Therapy  Youngstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-6639","authenticated-orcid":false,"given":"Marissa J.","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions, Inc.  Bozeman Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-7056","authenticated-orcid":false,"given":"Charles M.","family":"Zelen","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.5.855"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.Sup4.S4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12642"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1245"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.03.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-005-0778-z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/bglass-2019-0006"},{"key":"e_1_2_8_10_1","first-page":"99","article-title":"Mesoporous silica\u2010based bioactive glasses for antibiotic\u2010free antibacterial 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